Document Detail

Quantifying in vivo hemodynamic response to exercise in patients with intermittent claudication and abdominal aortic aneurysms using cine phase-contrast MRI.
MedLine Citation:
PMID:  20099356     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate rest and exercise hemodynamics in patients with abdominal aortic aneurysms (AAA) and peripheral occlusive disease (claudicants) using phase-contrast MRI.
MATERIALS AND METHODS: Blood velocities were acquired by means of cardiac-gated cine phase-contrast in a 0.5 Tesla (T) open MRI. Volumetric flow was calculated at the supraceliac (SC), infrarenal (IR), and mid-aneurysm (MA) levels during rest and upright cycling exercise using an MR-compatible exercise cycle.
RESULTS: Mean blood flow increased during exercise (AAA: 130%, Claudicants: 136% of resting heart rate) at the SC and IR levels for AAA participants (2.6 +/- 0.6 versus 5.8 +/- 1.6 L/min, P < 0.001 and 0.8 +/- 0.4 versus 5.1 +/- 1.7 L/min, P < 0.001) and claudicants (2.3 +/- 0.5 versus 4.5 +/- 0.9 L/min, P < 0.005 and 0.8 +/- 0.2 versus 3.3 +/- 0.9 L/min, P < 0.005). AAA participants had a significant decrease in renal and digestive blood flow from rest to exercise (1.8 +/- 0.7 to 0.7 +/- 0.6 L/min, P < 0.01). The decrease in renal and digestive blood flow during exercise correlated with daily activity level for claudicants (R = 0.81).
CONCLUSION: Abdominal aortic hemodynamic changes due to lower extremity exercise can be quantified in patients with AAA and claudication using PC-MRI. The redistribution of blood flow during exercise was significant and different between the two disease states.
Adam S Tenforde; Christopher P Cheng; Ga-Young Suh; Robert J Herfkens; Ronald L Dalman; Charles A Taylor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  31     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-15     Revised Date:  2014-04-16    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
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MeSH Terms
Aortic Aneurysm, Abdominal / complications*,  diagnosis*
Exercise Test*
Image Enhancement / methods*
Intermittent Claudication / diagnosis*,  etiology*
Magnetic Resonance Imaging, Cine / methods*
Reproducibility of Results
Sensitivity and Specificity
Grant Support
P41 RR009784/RR/NCRR NIH HHS; P41 RR009784-09/RR/NCRR NIH HHS; P41 RR09784/RR/NCRR NIH HHS; P50 HL083800/HL/NHLBI NIH HHS; P50 HL083800/HL/NHLBI NIH HHS; P50 HL083800-017474/HL/NHLBI NIH HHS; R01 HL064338/HL/NHLBI NIH HHS; R01 HL064338/HL/NHLBI NIH HHS; R01 HL064338-08W1/HL/NHLBI NIH HHS

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