| Quantifying in vivo hemodynamic response to exercise in patients with intermittent claudication and abdominal aortic aneurysms using cine phase-contrast MRI. | |
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MedLine Citation:
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PMID: 20099356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate rest and exercise hemodynamics in patients with abdominal aortic aneurysms (AAA) and peripheral occlusive disease (claudicants) using phase-contrast MRI. MATERIALS AND METHODS: Blood velocities were acquired by means of cardiac-gated cine phase-contrast in a 0.5 Tesla (T) open MRI. Volumetric flow was calculated at the supraceliac (SC), infrarenal (IR), and mid-aneurysm (MA) levels during rest and upright cycling exercise using an MR-compatible exercise cycle. RESULTS: Mean blood flow increased during exercise (AAA: 130%, Claudicants: 136% of resting heart rate) at the SC and IR levels for AAA participants (2.6 +/- 0.6 versus 5.8 +/- 1.6 L/min, P < 0.001 and 0.8 +/- 0.4 versus 5.1 +/- 1.7 L/min, P < 0.001) and claudicants (2.3 +/- 0.5 versus 4.5 +/- 0.9 L/min, P < 0.005 and 0.8 +/- 0.2 versus 3.3 +/- 0.9 L/min, P < 0.005). AAA participants had a significant decrease in renal and digestive blood flow from rest to exercise (1.8 +/- 0.7 to 0.7 +/- 0.6 L/min, P < 0.01). The decrease in renal and digestive blood flow during exercise correlated with daily activity level for claudicants (R = 0.81). CONCLUSION: Abdominal aortic hemodynamic changes due to lower extremity exercise can be quantified in patients with AAA and claudication using PC-MRI. The redistribution of blood flow during exercise was significant and different between the two disease states. |
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Authors:
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Adam S Tenforde; Christopher P Cheng; Ga-Young Suh; Robert J Herfkens; Ronald L Dalman; Charles A Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-15 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 425-9 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, Stanford University, Stanford, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Aneurysm, Abdominal / complications*, diagnosis* Exercise Test* Humans Image Enhancement / methods* Intermittent Claudication / diagnosis*, etiology* Magnetic Resonance Imaging, Cine / methods* Male Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR009784-09/RR/NCRR NIH HHS; P41 RR09784/RR/NCRR NIH HHS; P50 HL083800/HL/NHLBI NIH HHS; P50 HL083800-017474/HL/NHLBI NIH HHS; R01 HL064338/HL/NHLBI NIH HHS; R01 HL064338-08W1/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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