Document Detail

Quantifying heterogeneity in human tumours using MRI and PET.
MedLine Citation:
PMID:  22265426     Owner:  NLM     Status:  Publisher    
Most tumours, even those of the same histological type and grade, demonstrate considerable biological heterogeneity. Variations in genomic subtype, growth factor expression and local microenvironmental factors can result in regional variations within individual tumours. For example, localised variations in tumour cell proliferation, cell death, metabolic activity and vascular structure will be accompanied by variations in oxygenation status, pH and drug delivery that may directly affect therapeutic response. Documenting and quantifying regional heterogeneity within the tumour requires histological or imaging techniques. There is increasing evidence that quantitative imaging biomarkers can be used in vivo to provide important, reproducible and repeatable estimates of tumoural heterogeneity. In this article we review the imaging methods available to provide appropriate biomarkers of tumour structure and function. We also discuss the significant technical issues involved in the quantitative estimation of heterogeneity and the range of descriptive metrics that can be derived. Finally, we have reviewed the existing clinical evidence that heterogeneity metrics provide additional useful information in drug discovery and development and in clinical practice.
Marie-Claude Asselin; James P B O'Connor; Ronald Boellaard; Neil A Thacker; Alan Jackson
Related Documents :
6981986 - A peripheralized digital image management system: prospectus.
24131226 - Fundus camera guided photoacoustic ophthalmoscopy.
21200206 - Postoperative quantitative assessment of reconstructive tissue status in a cutaneous fl...
8796676 - Interpretation of calcifications in screen/film, digitized, and wavelet-enhanced monito...
1765436 - Fatty liver. chemical shift phase-difference and suppression magnetic resonance imaging...
24428856 - Half-time tc-99m sestamibi imaging with a direct conversion molecular breast imaging sy...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-19
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  -     ISSN:  1879-0852     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Wolfson Molecular Imaging Centre, University of Manchester, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modulation of central corneal thickness by various riboflavin eyedrop compositions in porcine cornea...
Next Document:  Inhibition of human hepatocellular carcinoma HepG2 by phthalocyanine photosensitiser ZnPcS(2)P(2): R...