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Quantifying the expression of VEGF using qRT-PCR, evaluation of MVD and their correlation with clinicopathological factors in laryngeal squamous cell carcinoma.
MedLine Citation:
PMID:  21595617     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES: In this study we quantified the expression of vascular endothelial growth factor (VEGF) using quantitative real-time polymerase chain reaction in laryngeal squamous cell carcinoma (LSCC) tissues and evaluated the correlation between the level of VEGF and microvessel density (MVD), and clinicopathological factors.
PATIENTS AND METHODS: Twenty-seven patients with LSCC undergoing total or partial laryngectomy at the Ear, Nose, and Throat and Head and Neck Surgery Department of the Izmir Tepecik Training and Research Hospital between September 2006 and July 2008. There was no VEGF expression in two patients that were excluded from the study. Twenty-five patients (24 males, 1 female; mean age 61 years; range 43 to 82 years) were included in this study, but MVD levels of 10 patients could not be determined.
RESULTS: As defined by the 2003 American Joint Committee on Cancer (AJCC) TNM classification, seven patients (28%) were stage 1, six patients (24%) were stage 2, four patients (16%) were stage 3, and eight patients (32%) were stage 4. Thirteen patients (52%) had well-differentiated (G1) tumors, and twelve had moderately differentiated tumors. Among the 15 patients for whom the MVD was determined, the median value was 48, with a (range 13-78; vessels / 3.76 mm2). Among the 25 patients for whom the VEGF level was determined, the median value was 0.035 vessels / 3.76 mm2 (range 0.010-0.127).
CONCLUSION: We could not find a statistical correlation between clinicopathological factors and either VEGF or MVD. Our study demonstrates that VEGF is expressed by LSCC.
Authors:
Pelin Koçdor; Işıl Coker; Umit Bayol; Deniz Altınel; Duygu Unüvar Purcu; Suat Kaptaner; Orhan Gazi Yiğitbaşı
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat     Volume:  21     ISSN:  1300-7475     ISO Abbreviation:  Kulak Burun Bogaz Ihtis Derg     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-05-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100899230     Medline TA:  Kulak Burun Bogaz Ihtis Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, İzmir Tepecik Training and Research Hospital, İzmir, Turkey. pelinkocdor@yahoo.com.
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