| Quantifying the duration of pre-diabetes. | |
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MedLine Citation:
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PMID: 20618275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Interventions for individuals with pre-diabetes are efficacious, however, identification of people with pre-diabetes does not occur in Australia. This study aims to calculate the duration of pre-diabetes, in order to provide supporting evidence for a screening program. METHODS: We carried out a systematic review and random effects meta-analysis to identify if an increased risk of mortality is present in people with pre-diabetes. The result of this meta-analysis as well as information on prevalence, remission of pre-diabetes and transition to diabetes from an Australian cohort study, were used in the software program DisMod to calculate duration. RESULTS: From 2,578 articles identified, 11 studies met the inclusion criteria. The pooled relative risk of all-cause mortality was 1.26 (1.17-1.34) with no sign of heterogeneity between the studies. The average duration of pre-diabetes was 8.5 years in males aged 30+ and 10.3 years in females aged 30+. CONCLUSIONS: The duration of pre-diabetes in Australia is long enough to warrant a screening program. The finding is robust to sensitivity testing of very large variations in the epidemiological parameters. IMPLICATIONS: If the interventions following screening are shown to be cost-effective, a strong rationale for the implementation of a screening program exists. |
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Authors:
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Melanie Y Bertram; Theo Vos |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Australian and New Zealand journal of public health Volume: 34 ISSN: 1753-6405 ISO Abbreviation: Aust N Z J Public Health Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9611095 Medline TA: Aust N Z J Public Health Country: Australia |
Other Details:
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Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
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Centre for Burden of Disease and Cost-Effectiveness, School of Population Health, Edith Cavell Building, Herston Rd, Herston QLD 4006. m.bertram@sph.uq.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Australia / epidemiology Diabetes Mellitus, Type 2 / prevention & control* Evidence-Based Medicine Female Glucose Intolerance / mortality* Humans Male Middle Aged Prediabetic State / mortality* Risk Sex Factors Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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