| Quantified T1 as an adjunct to apparent diffusion coefficient for early infarct detection: a high-field magnetic resonance study in a rat stroke model. | |
| | |
MedLine Citation:
|
PMID: 19659815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Thrombolytic treatment for acute stroke has focused attention on accurate identification of injured vs. salvageable brain tissue, particularly if reperfusion occurs. However, our knowledge of differences in acute magnetic resonance imaging changes between transient and permanent ischemia and how they reflect permanently damaged tissue remain incomplete. AIMS AND/OR HYPOTHESIS: Magnetic resonance imaging characteristics vary widely following ischemia and, at acute times, T1, T2 or apparent diffusion coefficient quantification may differentiate viable tissue from that destined to infarct. METHODS: High-resolution magnetic resonance imaging was performed at 9.4 T following permanent or transient (90 min) middle cerebral artery occlusion in spontaneously hypertensive male rats or Wistar rats. Within 30 min, quantified maps of the apparent diffusion coefficient, T1, and T2 were performed and measures determined for sequences in the infarct and compared with that in the contralateral region. Lesion area for each magnetic resonance imaging sequence (T1, T2, apparent diffusion coefficient, and perfusion maps) was delineated for different time points using quantitative threshold measures and compared with final histological damage. RESULTS: Early extensive changes in T1 following both transient and permanent middle cerebral artery occlusion provided a sensitive early indicator of the final infarct area. Following reperfusion, small but measurable early T2 changes indicative of early development of vasogenic edema occurred in the transient but not permanent groups. In transient middle cerebral artery occlusion, at 70 min apparent diffusion coefficient decreased (P<0.001) and then pseudonormalized at 150 min. In permanent middle cerebral artery occlusion, apparent diffusion coefficient declined over time. Lesion area detected using T1 maps exceeded that with T2 and apparent diffusion coefficient at 70 and 150 min in both groups (P<0.001). CONCLUSIONS: The results indicate that, independent of reperfusion, quantified T1 is superior for detecting early ischemic changes that are not necessarily detected with T2 or apparent diffusion coefficient. |
| | |
Authors:
|
J Kaur; U I Tuor; Z Zhao; J Petersen; A Y Jin; P A Barber |
Related Documents
:
|
22331255 - L: -5-hydroxytryptophan resets the circadian locomotor activity rhythm of the nocturnal... 12637695 - Detection of diffusion-weighted mri abnormalities in patients with transient ischemic a... 15968145 - Assessment of tissue viability using diffusion- and perfusion-weighted mri in hyperacut... 1708645 - Diffusion-weighted mr imaging and t2-weighted mr imaging in acute cerebral ischaemia: c... 8793815 - Meniscal ossicle. 9038125 - Determination of normal splenic volume on computed tomography in relation to age, gende... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of stroke : official journal of the International Stroke Society Volume: 4 ISSN: 1747-4949 ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-08-07 Completed Date: 2009-10-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101274068 Medline TA: Int J Stroke Country: England |
Other Details:
|
Languages: eng Pagination: 159-68 Citation Subset: IM |
Affiliation:
|
Department of Clinical Neurosciences, Experimental Imaging Centre, Faculty of Medicine, University of Calgary, Calgary, AB, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Gas Analysis Blood Pressure / physiology Body Temperature / physiology Brain / pathology Cerebrovascular Circulation Diffusion Magnetic Resonance Imaging Image Processing, Computer-Assisted / methods* Infarction, Middle Cerebral Artery / diagnosis*, pathology Male Rats Rats, Inbred SHR Rats, Wistar Stroke / diagnosis*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caring for stroke survivors: baseline and 1-year determinants of caregiver burden.
Next Document: Surveillance of trend and distribution of stroke mortality by subtype, age, gender, and geographic a...