| Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. | |
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MedLine Citation:
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PMID: 21448966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the reproducibility of proton MR spectroscopy ((1) H-MRS) for assessing vertebral bone marrow adiposity at 3 Tesla (T); to evaluate variation of marrow adiposity at different vertebral levels; and to demonstrate the feasibility of using (1) H-MRS at 3T for evaluating marrow adiposity in subjects with low bone density. MATERIALS AND METHODS: Single voxel MRS was acquired at vertebral body L1 to L4 at 3T in 51 postmenopausal females including healthy controls (n = 13) and patients with osteoporosis/osteopenia (n = 38). Marrow fat contents were compared between vertebral levels and between groups using analysis of variance (ANOVA). Six subjects were scanned twice to evaluate technique reproducibility. RESULTS: The average coefficient of variation of vertebral marrow fat content quantification was 1.7%. Marrow fat content significantly increased from L1 to L4. The average fat content was significantly elevated in patients with osteoporosis/osteopenia compared with controls, adjusted for age and body mass index (P < 0.05). CONCLUSION: In vivo MRS at high field strength provides reliable measurement of marrow adiposity with excellent reproducibility and can be a valuable tool for providing complementary information on bone quality and potentially also fracture risk. |
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Authors:
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Xiaojuan Li; Daniel Kuo; Anne L Schafer; Anne Porzig; Thomas M Link; Dennis Black; Ann V Schwartz |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: 2011-08-09 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 974-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA. xiaojuan.li@ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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pathology Aged Body Mass Index Bone Density Bone Diseases, Metabolic / pathology Cohort Studies Female Humans Image Processing, Computer-Assisted / methods Magnetic Resonance Spectroscopy / methods* Middle Aged Osteoporosis / pathology Osteoporosis, Postmenopausal / diagnosis, pathology* Reproducibility of Results Spine / pathology |
| Grant Support | |
ID/Acronym/Agency:
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RC1AR058405-01/AR/NIAMS NIH HHS; UL1 RR024131-01/RR/NCRR NIH HHS; UL1 RR024131-01/RR/NCRR NIH HHS |
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