Document Detail

Quantification of unscheduled DNA synthesis in mononuclear leukocytes of the horse.
MedLine Citation:
PMID:  4028689     Owner:  NLM     Status:  MEDLINE    
This study compares the relationship between N-acetoxy-2-acetylaminofluorene (NA-AAF) and u.v. induced unscheduled DNA synthesis (UDS) and their respective relationships to age and blood pressure in horse mononuclear leukocytes with earlier, similar investigations on human leukocytes. U.v. induced UDS was found to proceed more rapidly than NA-AAF induced UDS. A pronounced lag period associated with the rapid demand for 3H-dThd into DNA after u.v. damage was observed. NA-AAF induced UDS correlated significantly with NA-AAF binding, age and the blood pressure of male horses. UDS values, induced by either method, were about half the level calculated for human leukocytes.
C Ostlund; R W Pero; D B Johnson
Related Documents :
7858449 - Effect of octreotide on hemodynamics and glucagon levels in portal hypertensive rabbits.
8160819 - Vascular ne responsiveness in portal hypertension: role of portal pressure and portosys...
1763399 - Hemodynamic monitoring and pulse oximetry during percutaneous gastrostomy and jejunosto...
11808819 - Carbamazepine decreases antihypertensive effect of nilvadipine.
3097249 - Possible melatonin involvement in the hypotensive effect of mao inhibitors.
1316859 - Lymphocyte beta 2-adrenoceptors and plasma catecholamines in patients with cirrhosis.
18525379 - Sex differences in risk factor control of treated hypertensives: a national primary hea...
23677389 - Age-related differences in tongue-palate pressures for strength and swallowing tasks.
25157159 - Highway proximity and black carbon from cookstoves as a risk factor for higher blood pr...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  81     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-09     Completed Date:  1985-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  787-92     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetoxyacetylaminofluorene / pharmacology
Blood Pressure
DNA Replication / drug effects,  radiation effects*
Horses / metabolism*
Monocytes / drug effects,  metabolism*,  radiation effects
Thymidine / blood
Ultraviolet Rays*
Reg. No./Substance:
50-89-5/Thymidine; 6098-44-8/Acetoxyacetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Alterations in rat lipid metabolism following ecdysterone treatment.
Next Document:  Microprocessor-based system for on-line analysis of respiratory responses to exercise.