Document Detail


Quantification of unscheduled DNA synthesis in mononuclear leukocytes of the horse.
MedLine Citation:
PMID:  4028689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compares the relationship between N-acetoxy-2-acetylaminofluorene (NA-AAF) and u.v. induced unscheduled DNA synthesis (UDS) and their respective relationships to age and blood pressure in horse mononuclear leukocytes with earlier, similar investigations on human leukocytes. U.v. induced UDS was found to proceed more rapidly than NA-AAF induced UDS. A pronounced lag period associated with the rapid demand for 3H-dThd into DNA after u.v. damage was observed. NA-AAF induced UDS correlated significantly with NA-AAF binding, age and the blood pressure of male horses. UDS values, induced by either method, were about half the level calculated for human leukocytes.
Authors:
C Ostlund; R W Pero; D B Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  81     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-09     Completed Date:  1985-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  787-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetoxyacetylaminofluorene / pharmacology
Animals
Blood Pressure
DNA Replication / drug effects,  radiation effects*
Horses / metabolism*
Kinetics
Monocytes / drug effects,  metabolism*,  radiation effects
Thymidine / blood
Ultraviolet Rays*
Chemical
Reg. No./Substance:
50-89-5/Thymidine; 6098-44-8/Acetoxyacetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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