Document Detail


Quantification and statistical modeling--part I: breathing-zone concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate.
MedLine Citation:
PMID:  19622637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a repeated exposure-assessment survey for task-based breathing-zone concentrations (BZCs) of monomeric and polymeric 1,6-hexamethylene diisocyanate (HDI) during spray painting on 47 automotive spray painters from North Carolina and Washington State. We report here the use of linear mixed modeling to identify the primary determinants of the measured BZCs. Both one-stage (N = 98 paint tasks) and two-stage (N = 198 paint tasks) filter sampling was used to measure concentrations of HDI, uretidone, biuret, and isocyanurate. The geometric mean (GM) level of isocyanurate (1410 microg m(-3)) was higher than all other analytes (i.e. GM < 7.85 microg m(-3)). The mixed models were unique to each analyte and included factors such as analyte-specific paint concentration, airflow in the paint booth, and sampler type. The effect of sampler type was corroborated by side-by-side one- and two-stage personal air sampling (N = 16 paint tasks). According to paired t-tests, significantly higher concentrations of HDI (P = 0.0363) and isocyanurate (P = 0.0035) were measured using one-stage samplers. Marginal R(2) statistics were calculated for each model; significant fixed effects were able to describe 25, 52, 54, and 20% of the variability in BZCs of HDI, uretidone, biuret, and isocyanurate, respectively. Mixed models developed in this study characterize the processes governing individual polyisocyanate BZCs. In addition, the mixed models identify ways to reduce polyisocyanate BZCs and, hence, protect painters from potential adverse health effects.
Authors:
Kenneth W Fent; Linda G Trelles Gaines; Jennifer M Thomasen; Sheila L Flack; Kai Ding; Amy H Herring; Stephen G Whittaker; Leena A Nylander-French
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Publication Detail:
Type:  Journal Article     Date:  2009-07-21
Journal Detail:
Title:  The Annals of occupational hygiene     Volume:  53     ISSN:  1475-3162     ISO Abbreviation:  Ann Occup Hyg     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2010-02-12     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0203526     Medline TA:  Ann Occup Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  677-89     Citation Subset:  IM    
Affiliation:
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants, Occupational / analysis*
Automobiles
Cyanates / analysis*
Environmental Monitoring / methods*
Filtration / instrumentation
Humans
Inhalation Exposure / prevention & control*
Models, Statistical
North Carolina
Occupational Exposure / prevention & control*
Paint*
Respiratory Protective Devices
Washington
Workplace
Grant Support
ID/Acronym/Agency:
R24 HD050924-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Cyanates; 822-06-0/1,6-hexamethylene diisocyanate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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