Document Detail

Quantification of respiratory parameters in patients with temporal lobe epilepsy.
MedLine Citation:
PMID:  17665014     Owner:  NLM     Status:  MEDLINE    
Dysfunction affecting cardiac or pulmonary systems has been postulated as a major factor in sudden death in epilepsy (SUDEP). Whilst the majority of studies of cardiorespiratory function have focused on changes during seizures, here we investigate whether epilepsy influences basal respiratory parameters in patients with temporal lobe epilepsy (TLE) during the interictal period. Spirometry was performed in 10 females and 10 males. Measurements of Vital Capacity (VC), Forced Vital Capacity (FVC), Forced Expiratory Volume in the first second (FEV1) and ratios of FEV1 to FVC (FEV1/FVC) were obtained, and these values were analyzed as percentages of predicted values. None of the patients had chronic obstructive pulmonary disease and no significant alterations in respiratory function tests were found among these patients. No association between seizure frequency, antiepileptic drugs and SUDEP could be found in this study. Although the study did not identify any specific respiratory abnormality in TLE patients during the interictal period, re-evaluation of clinical data on pulmonary disorders in people with epilepsy should be better investigated.
Fulvio Alexandre Scorza; Ana Maria Fonseca Abreu; Marly de Albuquerque; Julio B Cota Pacheco; Renato Breviglieri; Josemir Wanderley Sander; Antônio Carlos da Silva; Esper Abrão Cavalheiro; Ricardo Mario Arida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  65     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-31     Completed Date:  2008-04-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  450-3     Citation Subset:  IM    
Laboratório de Neurologia Experimental, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brasil.
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MeSH Terms
Epilepsy, Temporal Lobe / physiopathology*
Forced Expiratory Volume / physiology*
Respiratory Mechanics / physiology*
Vital Capacity / physiology*

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