Document Detail

Quantification of renal perfusion using an intravascular contrast agent (part 1): results in a canine model.
MedLine Citation:
PMID:  12541248     Owner:  NLM     Status:  MEDLINE    
In this work absolute values of regional renal blood volume (rRBV) and flow (rRBF) are assessed by means of contrast-enhanced (CE) MRI using an intravascular superparamagnetic contrast agent. In an animal study, eight foxhounds underwent dynamic susceptibility-weighted MRI upon injection of contrast agent. Using principles of indicator dilution theory and deconvolution analysis, parametric images of rRBV, rRBF, and mean transit time (MTT) were computed. For comparison, whole-organ blood flow was determined invasively by means of an implanted flow probe, and the weight of the kidneys was evaluated postmortem. A mean rBV value of 28 ml/100 g was found in the renal cortex, with a corresponding mean rBF value of 524 ml/100 g/min and an average MTT of about 3.4 s. Although there was a systematic difference between the absolute blood flow values determined by MRI and the ultrasonic probe, a significant correlation (r(s) = 0.72, P < 0.05) was established. The influence of the arterial input function (AIF), T(1) relaxation effects, and repeated measurements on the precision of the perfusion quantitation is discussed.
Silke Aumann; Stefan O Schoenberg; Armin Just; Karen Briley-Saebo; Atle Bjørnerud; Michael Bock; Gunnar Brix
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  49     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-23     Completed Date:  2003-05-08     Revised Date:  2009-12-02    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  276-87     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
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MeSH Terms
Blood Volume
Contrast Media / administration & dosage*
Ferrosoferric Oxide
Image Processing, Computer-Assisted
Infusions, Intravenous
Iron / administration & dosage,  diagnostic use*
Magnetic Resonance Imaging*
Oxides / administration & dosage,  diagnostic use*
Renal Circulation*
Reg. No./Substance:
0/Contrast Media; 0/Oxides; 0/ferumoxtran-10; 1317-61-9/Ferrosoferric Oxide; 7439-89-6/Iron; 9004-54-0/Dextrans

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