| Quantification of regional left ventricular dyssynchrony by magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 18334390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac resynchronization therapy is an established treatment in patients with symptomatic heart failure and intraventricular conduction delay. Electrical dyssynchrony is typically adopted to represent myocardial activation dyssynchrony, which should be compensated by cardiac resynchronization therapy. One third of the patients, however, does not respond to the therapy. Therefore, imaging modalities aimed at the mechanical dyssynchrony estimation have been recently proposed to improve patient selection criteria. This paper presents a novel fully automated method for regional mechanical left ventricular dyssynchrony quantification in short-axis magnetic resonance imaging. The endocardial movement is described by time-displacement curves with respect to an automatically determined reference point. Different methods are proposed for time-displacement curve analysis aimed at the regional contraction timing estimation. These methods were evaluated in two groups of subjects with (nine patients) and without (six patients) left bundle branch block. The contraction timing standard deviation showed a significant increase for left bundle branch block patients with all the methods. A novel method based on phase spectrum analysis may be however preferred due to a better specificity (99.7%) and sensitivity (99.0%). In conclusion, this method provides a valuable prognostic indicator for heart failure patients with dyssynchronous ventricular contraction and it opens new possibilities for regional timing analysis. |
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Authors:
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Massimo Mischi; Harrie M van den Bosch; Annemieke M Jansen; Mischa Sieben; Ronald M Aarts; Hendrikus M Korsten |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 55 ISSN: 0018-9294 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-12 Completed Date: 2008-04-15 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 985-95 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering, Eindhoven University of Technology, P.O. Box 513, Eindhoven 5600 MB, The Netherlands. m.mischi@tue.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Bundle-Branch Block / complications, diagnosis*, physiopathology* Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging, Cine / methods* Myocardial Contraction* Reproducibility of Results Sensitivity and Specificity Ventricular Dysfunction, Left / diagnosis*, etiology, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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