Document Detail

Quantification of regional functional improvement of infarcted myocardium after primary PTCA by contrast-enhanced magnetic resonance imaging.
MedLine Citation:
PMID:  19161193     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess with cardiac magnetic resonance imaging (CMR) the relationship between treatment delay and improvement of regional left ventricular function after primary percutaneous transluminal coronary angioplasty (p-PTCA) for acute myocardial infarction (AMI). MATERIALS AND METHODS: We performed cine- and late-enhancement (LE) CMR in 40 patients with first AMI after restoring TIMI 3 flow with p-PTCA and at a follow-up 4 months later. Infarcted segments were determined from LE images. Regional left ventricular function was quantified from cine-CMR images. Segmentation followed the American Heart Association 17-segments model. Patients were divided into groups with delay <3 hours, 3-6 hours, 6-12 hours, and a delay >12 hours. RESULTS: Segmental wall thickening (SWT) significantly iproved only in segments reperfused within 6 hours (P < 0.001). Follow-up SWT was significantly higher if segments were reperfused early (<3 hours: 74 +/- 4%, 3-6 hours: 57 +/- 4%, 6-12 hours: 48 +/- 7%, <3 to 3-6: P < 0.003, and <3 to 6-12 hours: P < 0.001). The extent of improvement was greater if delay was <3 hours compared to segments with a delay of >3 hours (<3 hours: +21 +/- 3%, 3-6 hours: +8 +/- 4%, 6-12 hours: +6 +/- 3%; <3 hours to 3-6 hours, and 6-12 h, P < 0.02). CONCLUSION: We quantitatively demonstrated that time to p-PTCA treatment significantly influences regional functional recovery of infarcted myocardium at a 4-month follow-up.
Gert Klug; Thomas Trieb; Michael Schocke; Michael Nocker; Elisabeth Skalla; Agnes Mayr; Martha Nowosielski; Kathrin Pedarnig; Thomas Bartel; Nico Moes; Otmar Pachinger; Bernhard Metzler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  IM    
Clinical Division of Cardiology, Medical University, Innsbruck, Austria.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Contrast Media / administration & dosage
Gadolinium DTPA / administration & dosage
Image Processing, Computer-Assisted
Magnetic Resonance Imaging, Cine / methods*
Middle Aged
Myocardial Infarction / physiopathology*,  therapy*
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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