Document Detail

Quantification of ovarian stromal Doppler signals in postmenopausal women receiving hormone replacement therapy.
MedLine Citation:
PMID:  12851521     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effect of continuous-combined hormone replacement therapy (HRT) on ovarian circulation, we used three-dimensional power Doppler ultrasound to assess ovarian stromal blood flow in postmenopausal women. DESIGN: Forty healthy, postmenopausal women were enrolled in this prospective, controlled study. They were divided into two groups: the control group (20 patients with no HRT treatment) and the HRT group [initially 20 patients, but later 15 patients who completed the study, using continuous-combined conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone (5 mg/day)]. All patients underwent transvaginal three-dimensional power Doppler ultrasonography at the time of recruitment and 3 months later. The ovarian stromal flow indices, including vascularization-flow index (VFI), flow index (FI), and vascularization index (VI), were measured. Blood withdrawals for serum follicle-stimulating hormone and estrogen level testing were obtained before and after 3 months of treatment. RESULTS: All the variables in the hormone profile showed significant difference (P < 0.05) after 3 months of treatment in the HRT group. Of interest, the three-dimensional power Doppler indices of ovarian stromal flow, VFI (0.13 +/- 0.11 --> 0.59 +/- 0.49), FI (30.47 +/- 12.06 --> 38.41 +/- 10.21), and VI (0.31 +/- 0.27 --> 1.12 +/- 0.95) all showed significant increase (P < 0.05) after 3 months of HRT treatment. CONCLUSIONS: There was a significant increase in ovarian stromal flow indices after 3 months of treatment in the HRT group, but not in the controls. Monitoring the ovarian flow changes by three-dimensional power Doppler may be of clinical importance when HRT is given.
Hsien-An Pan; Chin-Hsien Li; Yueh-Chin Cheng; Meng-Hsing Wu; Fong-Ming Chang
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  10     ISSN:  1072-3714     ISO Abbreviation:  Menopause     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-72     Citation Subset:  IM    
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan, Taiwan.
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MeSH Terms
Estradiol / blood
Estrogen Replacement Therapy*
Estrogens, Conjugated (USP) / pharmacology
Imaging, Three-Dimensional
Medroxyprogesterone / pharmacology
Middle Aged
Ovary / blood supply*,  ultrasonography*
Progesterone Congeners / pharmacology
Prospective Studies
Regional Blood Flow
Ultrasonography, Doppler
Reg. No./Substance:
0/Estrogens, Conjugated (USP); 0/Progesterone Congeners; 50-28-2/Estradiol; 520-85-4/Medroxyprogesterone

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