Document Detail

Quantification of ovarian Doppler signal in hyperresponders during in vitro fertilization treatment using three-dimensional power Doppler ultrasonography.
MedLine Citation:
PMID:  12878236     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that the increased ovarian sensitivity to gonadotropins observed in women embarking on an in vitro fertilization (IVF) treatment may be due to changes in ovarian stromal blood flow, we undertook this prospective comparative clinical study using three-dimensional (3-D) power Doppler ultrasound (US). The 3-D power Doppler ultrasonographic indexes were used to quantify ovarian stromal blood flow and vascularization in hyperresponders. A total of 58 patients undergoing an IVF cycle were recruited and divided into two groups, a hyperresponder group (n = 23) (peak estradiol > 3000 pg/mL or >/= 15 oocytes retrieved) and normal responders (n = 35), based on their response to a standard down-regulation protocol for controlled ovarian stimulation. During ovarian stimulation, on the day of human chorionic gonadotropin (HCG) administration, patients underwent hormonal (serum E2), ovarian volume and 3-D power Doppler (ovarian stroma flow) evaluation. The serum estradiol levels on the day of HCG administration, the number of oocytes retrieved and the ovarian volume were significantly higher in the hyperresponders than in the normal groups. The vascularization flow index (VFI), flow index (FI), and vascularization index (VI), were significantly higher (p < 0.05) in the hyperresponders (1.18 +/- 0.60, 50.23 +/- 2.81 and 2.27 +/- 1.08, respectively), compared to the women with a normal response (0.63 +/- 0.61, 43.19 +/- 7.81 and 1.25 +/- 1.18, respectively). Our study may help to explain the excessive response during gonadotropin administration in the hyperresponsive women.
Hsien-An Pan; Meng-Hsing Wu; Yueh-Chin Cheng; Li-Hsiang Wu; Fong-Ming Chang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  29     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-24     Completed Date:  2003-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  921-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hospital, National Cheng Kung University, Tainan, Taiwan.
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MeSH Terms
Chorionic Gonadotropin / therapeutic use
Estradiol / blood
Fertilization in Vitro*
Imaging, Three-Dimensional*
Ovary / blood supply*,  drug effects,  ultrasonography*
Prospective Studies
Regional Blood Flow
Statistics, Nonparametric
Stimulation, Chemical
Ultrasonography, Doppler / methods*
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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