Document Detail

Quantification of neutrophil migration into the lungs of patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  21308374     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To quantify neutrophil migration into the lungs of patients with chronic pulmonary obstructive disease (COPD).
METHODS: Neutrophil loss via airways was assessed by dedicated whole-body counting 45 min, 24 h and 2, 4, 7 and 10 days after injection of very small activities of (111)In-labelled neutrophils in 12 healthy nonsmokers, 5 healthy smokers, 16 patients with COPD (of whom 7 were ex-smokers) and 10 patients with bronchiectasis. Lung accumulation of (99m)Tc-labelled neutrophils was assessed by sequential SPECT and Patlak analysis in six COPD patients and three healthy nonsmoking subjects.
RESULTS: Whole body (111)In counts, expressed as percentages of 24 h counts, decreased in all subjects. Losses at 7 days (mean ± SD) were similar in healthy nonsmoking subjects (5.5 ± 1.5%), smoking subjects (6.5 ± 4.4%) and ex-smoking COPD patients (5.8 ± 1.5%). In contrast, currently smoking COPD patients showed higher losses (8.0 ± 3.0%) than healthy nonsmokers (p = 0.03). Two bronchiectatic patients lost 25% and 26%, indicating active disease; mean loss in the remaining eight was 6.9 ± 2.5%. The rate of accumulation of (99m)Tc-neutrophils in the lungs, determined by sequential SPECT, was increased in COPD patients (0.030-0.073 min(-1)) compared with healthy nonsmokers (0-0.002 min(-1); p = 0.02).
CONCLUSION: In patients with COPD, sequential SPECT showed increased lung accumulation of (99m)Tc-labelled neutrophils, while whole-body counting demonstrated subsequent higher losses of (111)In-labelled neutrophils in patients who continued to smoke. Sequential SPECT as a means of quantifying neutrophil migration deserves further evaluation.
Prina Ruparelia; Katherine R Szczepura; Charlotte Summers; Chandra K Solanki; Kottekkattu Balan; Paul Newbold; Diana Bilton; A Michael Peters; Edwin R Chilvers
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-10
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  38     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-07-22     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  911-9     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Biological Transport
Cell Count
Cell Movement*
Indium Radioisotopes / metabolism
Lung / immunology*,  metabolism,  radionuclide imaging
Middle Aged
Neutrophil Infiltration*
Neutrophils / cytology*,  immunology*,  radionuclide imaging
Organotechnetium Compounds / diagnostic use,  metabolism
Pulmonary Disease, Chronic Obstructive / immunology*,  metabolism,  radionuclide imaging
Sputum / immunology
Tomography, Emission-Computed, Single-Photon
Grant Support
077940//Wellcome Trust
Reg. No./Substance:
0/Indium Radioisotopes; 0/Organotechnetium Compounds

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