| Quantification of the magnetic resonance signal response to dynamic (C)O(2)-enhanced imaging in the brain at 3 T: R*(2) BOLD vs. balanced SSFP. | |
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MedLine Citation:
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PMID: 20512881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare two magnetic resonance (MR) contrast mechanisms, R*(2) BOLD and balanced SSFP, for the dynamic monitoring of the cerebral response to (C)O(2) respiratory challenges. MATERIALS AND METHODS: Carbogen and CO(2)-enriched air were delivered to 9 healthy volunteers and 1 glioblastoma patient. The cerebral response was recorded by two-dimensional (2D) dynamic multi-gradient-echo and passband-balanced steady-state free precession (bSSFP) sequences, and local changes of R*(2) and signal intensity were investigated. Detection sensitivity was analyzed by statistical tests. An exponential signal model was fitted to the global response function delivered by each sequence, enabling quantitative comparison of the amplitude and temporal behavior. RESULTS: The bSSFP signal changes during carbogen and CO(2)/air inhalation were lower compared with R*(2) BOLD (ca. 5% as opposed to 8-13%). The blood-oxygen-level-dependent (BOLD) response amplitude enabled differentiation between carbogen and CO(2)/air by a factor of 1.4-1.6, in contrast to bSSFP, where differentiation was not possible. Furthermore, motion robustness and detection sensitivity were higher for R*(2) BOLD. CONCLUSION: Both contrast mechanisms are well suited to dynamic (C)O(2)-enhanced MR imaging, although the R*(2) BOLD mechanism was demonstrated to be superior in several respects for the chosen application. This study suggests that the R*(2) BOLD and bSSFP-response characteristics are related to different physiologic mechanisms. |
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Authors:
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Stefanie Remmele; Hannes Dahnke; Sebastian Flacke; Martin Soehle; Ingobert Wenningmann; Attila Kovacs; Frank Träber; Andreas Müller; Winfried A Willinek; Roy König; Hans Clusmann; Jürgen Gieseke; Hans H Schild; Petra Mürtz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 31 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1300-10 Citation Subset: IM |
Affiliation:
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Philips Research, 22335 Hamburg, Germany. stefanie.remmele@philips.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / pathology* Brain Neoplasms / metabolism, pathology, therapy Carbon Dioxide / chemistry* Diagnostic Imaging / methods Female Glioblastoma / metabolism, pathology, therapy* Humans Magnetic Resonance Imaging / methods* Male Oxygen / blood*, chemistry Sensitivity and Specificity Time Factors |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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