| Quantification of liver Fat in mice: comparing dual-echo dixon imaging, chemical shift imaging and 1H-MR spectroscopy. | |
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MedLine Citation:
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PMID: 21737754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We evaluate dual-echo Dixon (in-phase and out-of-phase, IP-OP), chemical shift imaging (CSI), and 1H MRS in estimating fat content (FC) in phantoms and livers of mice. Phantoms were made according to the volume percentage of fat ranging from 0% to 100%. Three MR methods were performed to measure FCs in phantoms, livers of ob/ob, human BSCL2/seipin gene knock-out (SKO) and wild type (WT) mice. The results were compared to known FCs in phantoms and to reference standard from mice by histological semi-automatic vacuole segmentation procedure (HIS-S) and liver lipid (LL) chemical analysis. In phantoms, CSI underestimated FC in range of 50-100%, to a smaller extent than IP-OP. In vivo, liver FCs in ob/ob and SKO mice measured by three MR methods were all significantly higher than that of WT mice. Liver FC measured by IP-OP are significantly lower than that measured by CSI and MRS with no significant difference between CSI and MRS. CSI and MRS showed a linear correlation with LL analysis and with each other. IP-OP underestimated FC, while CSI and MRS are more accurate for quantifying fat in both phantoms and liver. CSI and MRS have the potential to replace HIS-S and LL analysis in longitudinal studies. |
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Authors:
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Xin-Gui Peng; Shenghong Ju; Yujiao Qi; Fang Fang; Xin Cui; George Liu; Yicheng Ni; Gao-Jun Teng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-7 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Southeast University, China; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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