Document Detail

Quantification of left ventricular volume and global function using a fast automated segmentation tool: validation in a clinical setting.
MedLine Citation:
PMID:  22850929     Owner:  NLM     Status:  Publisher    
Real-time 3D echocardiography (RT3DE) has already been shown to be an accurate tool for left ventricular (LV) volume assessment. However, LV border detection in RT3DE remains a time-consuming task jeopardizing the application of this modality in routine practice. We have recently developed a 3D automated segmentation framework (BEAS) able to capture the LV morphology in real-time. The goal of this study was to assess the accuracy of this approach in extracting volumetric parameters in a clinical setting. 24 RT3DE exams were acquired in a group of healthy volunteers (# = 5) and diseased patients (# = 19), with LV volume/function within a range typically measured in a clinical setting. End-diastolic and end-systolic volumes (EDV, ESV) were manually contoured by 3 expert sonographers from which the stroke volume and ejection fraction (SV, EF) were calculated. The values extracted with BEAS were compared to the average of the 3 experts measurements using correlation and Bland-Altman statistics. Linear regression analysis showed a strong correlation between the automated algorithm and the reference values (R = 0.963, 0.947, 0.944 and 0.853 for EDV, ESV, SV and EF respectively). Bland-Altman analysis revealed a bias (limits of agreement) of 2.59 (-25.39, 30.57) ml, -2.11 (-24.91, 20.69) ml, 4.70 (12.93, 22.34) ml and 3.45 (-8.96, 15.87) %, for EDV, ESV, SV and EF respectively. Total analysis time using BEAS was 30.7 ± 7.5 s. BEAS allows for a fast and accurate quantification of 3D cardiac volumes and global function with minimal user input. It may therefore contribute to the integration of 3D echocardiography in routine clinical practice.
Daniel Barbosa; Brecht Heyde; Thomas Dietenbeck; Helene Houle; Denis Friboulet; Olivier Bernard; Jan D'hooge
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  -     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory on Cardiovascular Imaging & Dynamics, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, bus 7003, 3000, Leuven, Belgium,
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