| Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls. | |
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MedLine Citation:
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PMID: 9052525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies indicated that eosinophils and mast cells accumulate and become activated in inflammatory bowel disorders. The aim of the study was to examine the presence of eosinophil and mast cell mediators in human stool samples of patients with inflammatory bowel disorders. We measured eosinophil cationic protein (ECP), eosinophil protein X (EPX), methylhistamine, and alpha 1-antitrypsin in fecal samples of 136 patients (62 Crohn's disease, 24 ulcerative colitis, 15 intestinal food allergy, 35 other gastrointestinal diseases) and 8 healthy controls. We found strongly elevated levels of ECP (median: 29, range: 0.4-1783 ng/g feces) and EPX (803, 10-33,225 ng/g) in all patients groups compared to controls (ECP: 1.5, 0.5-55 ng/g; EPX: 235, 12-746 ng/g). Similar results, albeit less pronounced, were obtained for methylhistamine and alpha 1-antitrypsin. Particularly high concentrations of ECP and EPX were found in patients with active mucosal inflammation. In conclusion, the study presents an easy and reliable method for the detection of fecal ECP, EPX, and methylhistamine and may provide a tool to gain insight into the pathogenesis of inflammatory bowel diseases and have potential as diagnostic test. |
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Authors:
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S C Bischoff; J Grabowsky; M P Manns |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 42 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-26 Completed Date: 1997-03-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 394-403 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Medical School of Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Proteins / analysis Chromatography, High Pressure Liquid Eosinophil Granule Proteins Eosinophil-Derived Neurotoxin Feces / chemistry* Female Food Hypersensitivity / metabolism Humans Inflammation Mediators / analysis* Inflammatory Bowel Diseases / metabolism* Male Methylhistamines / analysis Middle Aged Ribonucleases* alpha 1-Antitrypsin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Inflammation Mediators; 0/Methylhistamines; 0/alpha 1-Antitrypsin; EC 3.1.-/Eosinophil-Derived Neurotoxin; EC 3.1.-/Ribonucleases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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