| Quantification of immunoglobulins and cytokines in human cervical mucus during each trimester of pregnancy. | |
| | |
MedLine Citation:
|
PMID: 11303193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Our aims were to determine immunoglobulin and cytokine levels in cervical mucus obtained from women during each trimester of pregnancy and to compare these levels with those reported in normally menstruating women and in women taking oral contraceptives. STUDY DESIGN: Cervical mucus samples were collected at specified intervals from 36 pregnant women. An enzyme-linked immunosorbent assay was used to quantitate the presence of immunoglobulins A and G and interleukins 1 beta, 6, and 10 in cervical mucus. RESULTS: Immunoglobulin A in cervical mucus remained stable during each trimester of pregnancy (26 mg/dL). Cervical mucus immunoglobulin G decreased from a first-trimester high of 44.4 mg/dL to lower levels in the second and third trimesters. Levels of interleukin 1 beta increased significantly from the first trimester (4261 pg/mL) to 12,899 pg/mL in the second trimester (P <.01). CONCLUSION: These data suggest a possible correlation of reproductive hormones and immunologic factors in the female reproductive tract during pregnancy. |
| | |
Authors:
|
W H Kutteh; R D Franklin |
Related Documents
:
|
8690283 - Benign cervical leiomyoma leading to disseminated fatal malignancy. 9641393 - Cervical varices: an unusual etiology for third-trimester bleeding. 8840173 - Amniotic fluid antibacterial activity and nutritional parameters in term mozambican and... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 184 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-04-16 Completed Date: 2001-05-31 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 865-72; discussion 872-4 Citation Subset: AIM; IM |
Affiliation:
|
Division of Reproductive Endocrinology and Immunology, Department of Obstetrics and Gynecology, University of Tennessee, Memphis, 38163-2116, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cervix Mucus / chemistry, immunology*, secretion Contraceptives, Oral, Hormonal / immunology Cytokines / immunology*, secretion Enzyme-Linked Immunosorbent Assay Estradiol / blood Female Humans Immunoglobulin A / analysis, immunology* Immunoglobulin G / analysis, immunology* Menstrual Cycle / immunology Pregnancy / blood, immunology* Progesterone / blood Sample Size |
| Grant Support | |
ID/Acronym/Agency:
|
1-R01-HD33168/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptives, Oral, Hormonal; 0/Cytokines; 0/Immunoglobulin A; 0/Immunoglobulin G; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical predictors of endometritis in women with symptoms and signs of pelvic inflammatory disease.
Next Document: The moral foundation of medical leadership: the professional virtues of the physician as fiduciary o...