| Quantification of heterocyclic amines from thermally processed meats selected from a small-scale population-based study. | |
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MedLine Citation:
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PMID: 18925613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heterocyclic amines (HAs) are potent mutagens that form at high temperatures in cooked, protein-rich food. Due to their frequent intake, these compounds are considered a risk factor for human cancer. Cooking conditions and eating habits strongly influence the level of HA exposure. Thus, it is difficult to assess the intake of HAs in a large population. Food-frequency questionnaires (FFQs), designed to provide data on parameters that affect HA formation, were used to survey a small population (459 persons) from Barcelona (NE Spain). Subsequently, the most-consumed food items named were cooked according to the preferences of the population surveyed and analyzed for HAs using SPE and LC-MS/MS. In the population studied, the estimated intake via consumption of 13 meat dishes was 285.6 ng of mutagenic HAs per capita and day. PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) was the HA to which the population was most exposed, mainly from fried chicken and griddled beef. When the co-mutagens norharman and harman are included, the mean daily intake of HAs rises to 475.6 ng per capita and day. A novel putative DMIP regioisomer was detected in the cooked meats, which was analyzed in the present study by multistage MS. |
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Authors:
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Rosa Busquets; David Mitjans; Lluís Puignou; Maria Teresa Galceran |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 52 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1408-20 Citation Subset: IM |
Affiliation:
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Department of Analytical Chemistry, Chemistry Faculty, University of Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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analysis* Cookery Diet Heterocyclic Compounds / analysis* Humans Imidazoles / administration & dosage, analysis* Mass Spectrometry Meat / analysis* Mutagens / analysis* Spain |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Heterocyclic Compounds; 0/Imidazoles; 0/Mutagens; 105650-23-5/2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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