| Quantification of free fatty acids in human cerebrospinal fluid. | |
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MedLine Citation:
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PMID: 11885776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Free fatty acids (FFA) in cerebrospinal fluid (CSF) are well-recognized markers of brain damage in animal studies. Information is limited regarding human CSF in both normal and pathological conditions. Samples of CSF from 73 patients, who had undergone lumbar puncture for medically indicated reasons, came from a core laboratory upon completion of ordered tests. Using high performance liquid chromatography, mean FFA concentrations (microg/L +/- SEM) were: arachidonic 26.14 +/- 3.44; docosahexaenoic 60.74 +/- 5.70; linoleic 105.07 +/- 10.98; myristic 160.38 +/- 16.17; oleic 127.91 +/- 10.13; and palmitic 638.34 +/- 37.27. No differences in FFA concentrations were seen with gender, race, age, and/or indication for lumbar puncture. This is the first study to document normal human CSF FFA concentrations in a large series. Further characterization of FFA in pathological conditions may provide markers for evaluating clinical treatments and assisting in prognostication of neurological disease. |
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Authors:
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J G Pilitsis; F G Diaz; J M Wellwood; M H Oregan; M R Fairfax; J W Phillis; W M Coplin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemical research Volume: 26 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-03-11 Completed Date: 2002-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 1265-70 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Wayne State University, Detroit, MI 48201, USA. jpilitsis@neurosurgery.wayne.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Fatty Acids, Nonesterified / cerebrospinal fluid* Female Humans Male Middle Aged Osmolar Concentration Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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