| Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage. | |
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MedLine Citation:
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PMID: 9705109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise-induced pulmonary haemorrhage (EIPH) causes serious economic losses in the horse racing industry. Endoscopic examination indicates that 40-90% of horses exhibit EIPH following sprint exercise, but the limitations of the endoscope prevent diagnosis in many horses. Bronchoalveolar lavage (BAL) was utilised to detect red blood cells (RBCs) in the terminal airways in 6 horses. Two lavages were performed at weekly intervals prior to exercise, one within 90 min after exercise, and 5 at weekly intervals after exercise. The horses were exercised strenuously at 12.5-14.6 m/s on a treadmill (3 degree incline). Heart rates ranged from 192-207 beats/min, and mean pulmonary arterial pressures (mPAP) ranged from 80-102 mmHg. Neither epistaxis nor endoscopic evidence of EIPH was seen in any of the 6 horses following exercise. However, the number of RBCs in the lavage fluid increased significantly over control values immediately after exercise in all horses but returned to control values by one week after exercise. Haemosiderophages in the BAL fluid did not increase until one week after exercise and remained elevated for 3 weeks after exercise. Twenty per cent of the total population of alveolar macrophages contained haemosiderin. A positive relationship occurred between the number of RBCs in the lavage fluid and mPAP; the amount of haemorrhage increased as the mPAP exceeded 80 to 90 mmHg. The results with BAL used as the diagnostic tool, suggest that all strenuously exercised horses may exhibit EIPH; the amount of haemorrhage appears to be associated with the magnitude of the high pulmonary arterial pressure. |
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Authors:
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T S Meyer; M R Fedde; E M Gaughan; I Langsetmo; H H Erickson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Equine veterinary journal Volume: 30 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-14 Completed Date: 1998-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 284-8 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / cytology* Bronchoscopy / veterinary Erythrocyte Count / veterinary Exercise Test / veterinary Heart Rate Hemorrhage / diagnosis, etiology, veterinary* Horse Diseases / diagnosis*, etiology Horses Leukocyte Count / veterinary Lung Diseases / diagnosis, etiology, veterinary* Macrophages, Alveolar / cytology Male Physical Conditioning, Animal / adverse effects* Pulmonary Wedge Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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