Document Detail


Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage.
MedLine Citation:
PMID:  9705109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exercise-induced pulmonary haemorrhage (EIPH) causes serious economic losses in the horse racing industry. Endoscopic examination indicates that 40-90% of horses exhibit EIPH following sprint exercise, but the limitations of the endoscope prevent diagnosis in many horses. Bronchoalveolar lavage (BAL) was utilised to detect red blood cells (RBCs) in the terminal airways in 6 horses. Two lavages were performed at weekly intervals prior to exercise, one within 90 min after exercise, and 5 at weekly intervals after exercise. The horses were exercised strenuously at 12.5-14.6 m/s on a treadmill (3 degree incline). Heart rates ranged from 192-207 beats/min, and mean pulmonary arterial pressures (mPAP) ranged from 80-102 mmHg. Neither epistaxis nor endoscopic evidence of EIPH was seen in any of the 6 horses following exercise. However, the number of RBCs in the lavage fluid increased significantly over control values immediately after exercise in all horses but returned to control values by one week after exercise. Haemosiderophages in the BAL fluid did not increase until one week after exercise and remained elevated for 3 weeks after exercise. Twenty per cent of the total population of alveolar macrophages contained haemosiderin. A positive relationship occurred between the number of RBCs in the lavage fluid and mPAP; the amount of haemorrhage increased as the mPAP exceeded 80 to 90 mmHg. The results with BAL used as the diagnostic tool, suggest that all strenuously exercised horses may exhibit EIPH; the amount of haemorrhage appears to be associated with the magnitude of the high pulmonary arterial pressure.
Authors:
T S Meyer; M R Fedde; E M Gaughan; I Langsetmo; H H Erickson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal     Volume:  30     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-09-14     Completed Date:  1998-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5602, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchoalveolar Lavage Fluid / cytology*
Bronchoscopy / veterinary
Erythrocyte Count / veterinary
Exercise Test / veterinary
Heart Rate
Hemorrhage / diagnosis,  etiology,  veterinary*
Horse Diseases / diagnosis*,  etiology
Horses
Leukocyte Count / veterinary
Lung Diseases / diagnosis,  etiology,  veterinary*
Macrophages, Alveolar / cytology
Male
Physical Conditioning, Animal / adverse effects*
Pulmonary Wedge Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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