Document Detail

Quantification of endogenous testosterone and dihydrotestosterone in fetal tissues from male guinea-pig.
MedLine Citation:
PMID:  7303030     Owner:  NLM     Status:  MEDLINE    
Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas deferens, epididymis, seminal vesicle) and the urogenital sinus (urogenital tubercle, prostate) when these tissues are differentiating between days 28 and 36 (T = 320 to 1450 and DHT = 200 to 860 pg/10 mg of tissue). During the same period circulating testosterone is taken up by the non-specific tissues (intestine, diaphragm) to a lesser degree (150 to 250 pg/10 mg) as well as by hypothalamus and hypophysis (100 to 170 pg/organ). After this uptake phase, T declines in the non-specific tissues to minimal concentrations (less than 10 pg/10 mg). Compared to the situations in the diaphragm and intestine, DHT concentrations were significantly higher in both urogenital sinus and Wolffian duct components, and T concentrations were significantly higher only in the Wolffian ducts components. In the bladder, T and DHT levels were significantly higher than those of the androgen-independent tissues.
N Rigaudière
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Steroids     Volume:  38     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-94     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Diaphragm / analysis
Dihydrotestosterone / analysis*
Fetus / analysis*
Guinea Pigs
Hypothalamus / analysis
Intestines / analysis
Pituitary Gland / analysis
Prostate / analysis
Testis / analysis
Testosterone / analysis*
Urinary Bladder / analysis
Reg. No./Substance:
521-18-6/Dihydrotestosterone; 58-22-0/Testosterone

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