| Quantification of deep and superficial sensibility in saline-induced muscle pain--a psychophysical study. | |
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MedLine Citation:
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PMID: 9583576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to study the sensibility in the area of saline-induced muscle pain. In three experiments, ten subjects were exposed to computer-controlled infusion of 0.5 ml isotonic (0.9%) or hypertonic (9%) saline into the anterior tibial muscle. The pain intensity was assessed on a visual analogue scale (VAS). The pain threshold (PT) to pressure and electrical stimulation in muscle and subcutaneous tissues was determined. Three experiments were performed in which infusion of hypertonic saline produced significantly higher VAS scores than isotonic saline. In all three experiments, there was no significant difference in PT obtained after infusion of isotonic saline compared with infusion of hypertonic saline. In experiment 1, the PT was determined at the infusion site and 4 cm from the infusion site. At the infusion site, the pressure PT decreased (-19 +/- 2%) 1, 3, 5, 7 and 9 min after infusion of isotonic and hypertonic saline, but remained unchanged 4 cm from the infusion site. The intramuscular electrical PT at the infusion site and 4 cm from the infusion site increased significantly (29 +/- 6%) 5, 7 and 9 min after saline infusion. In experiment 2, the pressure PT and the intramuscular electrical PT were recorded after two infusions of saline separated by 1 day. The day after the first infusion, the pressure PT was decreased compared with the PT before the first infusion, but the electrical PT was not affected. Moreover, the hypertonic saline infusion given on the second day produced significantly higher (130 +/- 50%) VAS scores than the infusion given on the first day. In experiment 3, the PT was determined in the subcutaneous tissue, but no significant effects of saline infusion were found. The present placebo-controlled experiments failed to show muscular or subcutaneous hyperalgesia after saline-induced muscle pain per se. |
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Authors:
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T Graven-Nielsen; L S Fenger-Grøn; P Svensson; K Steengaard-Pedersen; L Arendt-Nielsen; T Staehelin Jensen |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Somatosensory & motor research Volume: 15 ISSN: 0899-0220 ISO Abbreviation: Somatosens Mot Res Publication Date: 1998 |
Date Detail:
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Created Date: 1998-07-01 Completed Date: 1998-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904127 Medline TA: Somatosens Mot Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 46-53 Citation Subset: IM |
Affiliation:
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Center for Sensory-Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Denmark. tgn@miba.auc.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biomechanics Electric Stimulation Female Humans Male Middle Aged Muscular Diseases / chemically induced, physiopathology* Pain / chemically induced, physiopathology* Pain Measurement Psychophysics Saline Solution, Hypertonic / pharmacology* Sodium Chloride / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Saline Solution, Hypertonic; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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