Document Detail

Quantification of coronary plaque by 64-slice computed tomography: a comparison with quantitative intracoronary ultrasound.
MedLine Citation:
PMID:  18424952     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Noninvasive assessment of coronary atherosclerotic plaque may be useful for risk stratification and treatment of atherosclerosis. MATERIALS AND METHODS: We studied 47 patients to investigate the accuracy of coronary plaque volume measurement acquired with 64-slice multislice computed tomography (MSCT), using newly developed quantification software, when compared with quantitative intracoronary ultrasound (QCU). Quantitative MSCT coronary angiography (QMSCT-CA) was performed to determine plaque volume for a matched region of interest (regional plaque burden) and in significant plaque defined as a plaque with > or =50% area obstruction in QCU, and compared with QCU. Dataset with image blurring and heavy calcification were excluded from analysis. RESULTS: In 100 comparable regions of interest, regional plaque burden was highly correlated (coefficient r = 0.96; P < 0.001) between QCU and QMSCT-CA, but QMSCT-CA overestimated the plaque burden by a mean difference of 7 +/- 33 mm3 (P = 0.03). In 76 significant plaques detected within the regions of interest, plaque volume determined by QMSCT-CA was highly correlated (r = 0.98; P < 0.001) with a slight underestimation of 2 +/- 17 mm3 (P = not significant) when compared with QCU. Calcified and mixed plaque volume was slightly overestimated by 4 +/- 19 mm3 (P = ns) and noncalcified plaque volume was significantly underestimated by 9 +/- 11 mm3 (P < 0.001) with QMSCT-CA. Overall, the limits of agreement for plaque burden/volume measurement between QCU and QMSCT-CA were relatively large. Reproducibility for the measurements of regional plaque burden with QMSCT-CA was good, with a mean intraobserver and interobserver variability of 0% +/- 16% and 4% +/- 24%, respectively. CONCLUSIONS: Quantification of coronary plaque within selected proximal or middle coronary segments without image blurring and heavy calcification with 64-slice CT was moderately accurate with respect to intravascular ultrasound and demonstrated good reproducibility. Further improvement in CT resolution is required for more reliable measurement of coronary plaques using quantification software.
Masato Otsuka; Nico Bruining; Niels C Van Pelt; Nico R Mollet; Jurgen M R Ligthart; Eleni Vourvouri; Ronald Hamers; Peter De Jaegere; William Wijns; Ron T Van Domburg; Gregg W Stone; Susan Veldhof; Stefan Verheye; Dariusz Dudek; Patrick W Serruys; Gabriel P Krestin; Pim J De Feyter
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  43     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-09-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-21     Citation Subset:  IM    
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Contrast Media / administration & dosage
Coronary Angiography / methods
Coronary Artery Disease / diagnosis*
Coronary Vessels / ultrasonography
Image Processing, Computer-Assisted / methods*
Iopamidol / analogs & derivatives,  diagnostic use
Middle Aged
Radiographic Image Enhancement / methods
Reproducibility of Results
Time Factors
Tomography, X-Ray Computed / methods*
Ultrasonography, Interventional / methods*
Reg. No./Substance:
0/Contrast Media; 62883-00-5/Iopamidol; 78649-41-9/iomeprol

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