| Quantification of coronary microvascular resistance using angiographic images for volumetric blood flow measurement: In-vivo validation. | |
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MedLine Citation:
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PMID: 21398596 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Structural coronary microcirculation abnormalities are important prognostic determinants in clinical settings. However, assessment of microvascular resistance (MR) requires a velocity wire. A first-pass distribution analysis (FPA) technique to measure volumetric blood flow has previously been validated. The aim of this study was the in vivo validation of the MR measurement technique using FPA. Methods: Twelve swine were instrumented with a transit-time ultrasound flow probe on the proximal segment of the left anterior descending (LAD) artery. Microspheres were injected into LAD to create microvascular dysfunction. Adenosine was used to produce maximum hyperemia. A region of interest in the LAD arterial bed was drawn to generate time-density curves using angiographic images. Volumetric blood flow measurements (Qa) were made using a time-density curve and the assumption that blood was momentarily replaced with contrast agent during the injection. Blood flow from the flow probe (Qp), coronary pressure and right atrium pressure were continuously recorded. Flow probe based normalized MR (NMRp) and angiography based normalized MR (NMRa) were calculated using Qp and Qa, respectively. Results: In 258 measurements, Qa showed a strong correlation with Qp (Qa=0.90Qp+6.6 ml/min, r2=0.91, p<0.0001). NMRa correlated linearly with NMRp (NMRa=0.90NMRp +0.02 mmHg/ml/min, r2=0.91, p<0.0001). Additionally, the Bland-Altman analysis showed a close agreement between NMRa and NMRp. Conclusions: A technique based on angiographic image data for quantifying NMR was validated using a swine model. This study provides a method to measure NMR, without using a velocity wire, which can potentially be used to evaluate microvascular conditions during coronary arteriography. |
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Authors:
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Zhang Zhang; Shigeho Takarada; Sabee Molloi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-11 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of California-Irvine. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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