Document Detail

Quantification of concentration changes in neonatal human cerebral oxidized cytochrome oxidase.
MedLine Citation:
PMID:  1662199     Owner:  NLM     Status:  MEDLINE    
The oxygenation of cerebral cytochrome oxidase in vivo was investigated in eight newborn preterm infants. Near-infrared spectroscopy was used to quantify changes in the concentration of oxidized cytochrome oxidase ([CytO2]) observed during alterations in arterial oxygen saturation (SaO2) in the range of 85-99% and of carbon dioxide tension (PaCO2) in the range of 4.3-9.6 kPa. No relation was found between changes in SaO2 and [CytO2]. Alterations in PaCO2 were positively related both to changes in [CytO2] and total cerebral hemoglobin concentration [( Hb]t). The changes in [CytO2] ranged from 0.09 to 0.33 (median 0.21) mumol.l-1.kPa-1. The ratio [CytO2]/[Hb]t ranged from 0.06 to 0.12 (median 0.08). The relation of delta [CytO2] to the change in cerebral blood volume (delta CBV) was calculated: delta [CytO2]/delta CBV ranged from 0.09 to 0.18 (median 0.11) mumol/ml. These results define a fraction of cerebral cytochrome oxidase in the newborn infant that is oxidized after an increase in PaCO2 but demonstrate that a change in SaO2 in the range studied was not sufficient by itself to change [CytO2]. They differ from results of studies in adults; this may reflect significant differences between adult and neonatal brain.
A D Edwards; G C Brown; M Cope; J S Wyatt; D C McCormick; S C Roth; D T Delpy; E O Reynolds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1907-13     Citation Subset:  IM    
Department of Paediatrics, University College and Middlesex School of Medicine, London, United Kingdom.
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MeSH Terms
Brain / enzymology*
Carbon Dioxide / blood
Cerebrovascular Circulation
Electron Transport Complex IV / metabolism*
Hemoglobins / metabolism
Infant, Newborn
Infant, Premature
Oxygen / blood
Spectrophotometry, Infrared
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Hemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; EC Transport Complex IV

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