Document Detail


Quantification of choline compounds in human hepatic tumors by proton MR spectroscopy at 3 T.
MedLine Citation:
PMID:  15799049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The quantification of choline-containing compounds (Cho) in hepatic tumors by (1)H MR spectroscopy (MRS) is of great interest because such compounds have been linked to malignancy. In this study, a practical external phantom replacement method for the absolute quantification of hepatic metabolites is demonstrated. We performed experiments at 3 T using a body coil, and used an external phantom containing choline chloride for calibration. We first tested the quantification strategy to confirm its suitability in vivo using a phantom of known concentration and normal brain tissue. The results obtained after coil loading and T(1) and T(2) effects were corrected for were consistent with the known concentration and previously published values. To demonstrate its feasibility, we applied the technique to liver studies conducted on five normal volunteers and four patients with hepatocellular carcinoma, and one patient (also in the latter group) who had undergone post-transcatheter arterial chemoembolization (TACE). The Cho concentrations in the four patients were estimated to be 3.4, 6.3, 7.4, and 14.0 mM, respectively. These values are substantially higher than those obtained from the healthy volunteers (1.3 +/- 0.9 mM (mean +/- SD)). The results indicate that the proposed method is accurate and requires fewer tedious procedures for MRS; therefore, it may be a promising technique for evaluating response to treatment in liver cancer.
Authors:
Chun-Wei Li; Yueh Chun Kuo; Chiao-Yun Chen; Yu-Ting Kuo; Yen-Yu Chiu; Feng-O She; Gin-Chung Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  53     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-04     Completed Date:  2005-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  770-6     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc.
Affiliation:
Faculty of Medical Radiation Technology, College of Health Sciences, 100 Shi-Chuan 1st Road, San Ming District, Kaohsiung City, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Brain / metabolism
Carcinoma, Hepatocellular / metabolism*
Choline / metabolism*
Humans
Liver / metabolism
Liver Neoplasms / metabolism*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy / methods*
Phantoms, Imaging
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Chemical
Reg. No./Substance:
62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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