Document Detail

Quantification of cerebral blood flow using technetium-99m ethyl cysteinate dimer and single-photon emission tomography.
MedLine Citation:
PMID:  10079315     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to develop a new method for quantifying regional cerebral blood flow (rCBF) with technetium-99m ethyl cysteinate dimer (ECD) and single-photon emission tomography (SPET). Employing a three-compartment model, we introduced a parameter, regional brain fractionation index (BFI), that reflects rCBF values and is obtained by a single SPET scan at optimum time T (min) after tracer injection and the integral of arterial input. By analysing the dynamic SPET and arterial blood sampling data of 15 subjects, including the results of acetazolamide challenges, with the graphical plot method, optimum time T was determined to be approximately 20 min post injection. Regional BFI values of each subject were calculated from the single SPET data at 20 min and arterial input. The relationship between the values of regional BFI and rCBF obtained by xenon-133 inhalation SPET was analysed by approximation with an exponential function, resulting in good agreement (r = 0.907). In the present method, rCBF values were determined from regional BFI values by using the inverse exponential function as a non-linear regression curve. To validate the method, we applied it to six other subjects, in whom acetazolamide challenges were also performed. In comparing rCBF values thus obtained and those obtained by 133Xe inhalation SPET, we found a good correlation (r = 0.901) with an inclination approximating 1 (= 1.02) and without underestimation of rCBF in the high-flow range. Since the present method does not require dynamic planar imaging or dynamic SPET scanning, it can be applied to any type of SPET scanner and is useful in clinical SPET studies.
I Odano; M Ohkubo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  26     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-16     Completed Date:  1999-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  246-52     Citation Subset:  IM    
Department of Radiology, Niigata University School of Medicine, Niigata, Japan.
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MeSH Terms
Brain / radionuclide imaging*
Case-Control Studies
Cerebrovascular Circulation / physiology*
Cerebrovascular Disorders / radionuclide imaging*
Cysteine / analogs & derivatives*,  diagnostic use
Middle Aged
Organotechnetium Compounds / diagnostic use*
Radiopharmaceuticals / diagnostic use*
Tomography, Emission-Computed, Single-Photon* / methods
Xenon Radioisotopes / diagnostic use
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/Xenon Radioisotopes; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine

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