Document Detail

Quantification of carotid blood flow velocity using MR phase mapping.
MedLine Citation:
PMID:  8089314     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the feasibility of a two-dimensional phase-sensitive MR technique [phase mapping (PM)] for the quantification of carotid blood flow velocity (CBFV) and pulsatility in normal subjects and patients with extracranial carotid disease. MATERIALS AND METHODS: Using PM, we measured the systolic peak, minimum diastolic, and mean CBFV and the pulsatility index in both common carotid arteries (CCAs) of 22 normal subjects and 32 patients. In addition, the CBFV was quantified in the internal carotid arteries (ICAs) of 25 patients. These data were compared with independent measurements based on pulsed-wave Doppler ultrasonography. RESULTS: Correlations between PM and pulsed-wave Doppler were strong for systolic peak CBFV in both the CCA (r = 0.91) and the ICA (r > or = 0.82). Slightly lower correlations were obtained for mean CBFV (r > or = 0.79) and minimum diastolic CBFV (r > or = 0.75), both measured in the CCA. Velocity waveform comparison revealed high between-method correlations for the CCA (r = 0.90 for normals; r > or = 0.88 for patients) and slightly lower correlations for the ICA (r > or = 0.75). Agreement was lower (r = 0.63) for measurements in the ICA distal to high grade stenosis. CONCLUSION: Phase mapping compared well with Doppler ultrasonography in quantifying CBFV and pulsatility in patients with extracranial carotid artery disease. Except for poststenotic measurements in high grade obstructive lesions, PM is capable of providing quantitative hemodynamic information on the severity of ICA stenosis.
G Fürst; M Sitzer; M Hofer; H Steinmetz; T Hackländer; E Müller; U Mödder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  18     ISSN:  0363-8715     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1994-10-14     Completed Date:  1994-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  688-96     Citation Subset:  IM    
Institute of Diagnostic Radiology, Heinrich Heine University, Düsseldorf, Germany.
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MeSH Terms
Aged, 80 and over
Arterial Occlusive Diseases / physiopathology*,  ultrasonography
Blood Flow Velocity / physiology
Carotid Arteries / physiology*,  ultrasonography
Carotid Artery Diseases / physiopathology*,  ultrasonography
Carotid Artery, Common / physiology,  ultrasonography
Carotid Artery, Internal / physiopathology,  ultrasonography
Constriction, Pathologic / physiopathology,  ultrasonography
Image Enhancement / methods
Magnetic Resonance Imaging / methods*
Middle Aged
Pulsatile Flow / physiology
Regional Blood Flow / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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