Document Detail

Quantification of cardiac magnetic field orientation during ventricular de- and repolarization.
MedLine Citation:
PMID:  18401064     Owner:  NLM     Status:  MEDLINE    
We compared the stability and discriminatory power of different methods of determining cardiac magnetic field map (MFM) orientation within the context of coronary artery disease (CAD). In 27 healthy subjects and 24 CAD patients, multichannel magnetocardiograms were registered at rest. MFM orientation was determined during QT interval using: (a) locations of the positive and negative centres-of-gravity, (b) locations of the field extrema and (c) the direction of the maximum field gradient. Deviation from normal orientation quantified the ability of each approach to discriminate between healthy and CAD subjects. Although the course of orientation was similar for all methods, receiver operating characteristic analysis showed the best discrimination of CAD patients for the centre-of-gravity approach (area-under-the-curve = 86%), followed by the gradient (84%) and extrema (76%) methods. Consideration of methodological and discriminatory advantages with respect to noninvasive diagnosis of CAD suggests that the centres-of-gravity method is the most suited one.
Peter Van Leeuwen; Birgit Hailer; Silke Lange; Anita Klein; Daniel Geue; Katrin Seybold; Christian Poplutz; Dietrich Grönemeyer
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Publication Detail:
Type:  Journal Article     Date:  2008-04-09
Journal Detail:
Title:  Physics in medicine and biology     Volume:  53     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2291-301     Citation Subset:  IM    
Department of Biomagnetism, Grönemeyer Institute of Microtherapy, Bochum, Germany.
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MeSH Terms
Area Under Curve
Case-Control Studies
Coronary Artery Disease / diagnosis*,  pathology
Electromagnetic Fields*
Heart Ventricles / pathology*
Magnetoencephalography / instrumentation,  methods
Middle Aged
ROC Curve
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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