Document Detail


Quantification of anaesthetic effects on atrial fibrillation rate by partial least-squares.
MedLine Citation:
PMID:  23011052     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The mechanism underlying atrial fibrillation (AF) remains poorly understood. Multiple wandering propagation wavelets drifting through both atria under hierarchical models are not understood. Some pharmacological drugs, known as antiarrhythmics, modify the cardiac ionic currents supporting the fibrillation process within the atria and may modify the AF propagation dynamics terminating the fibrillation process. Other medications, theoretically non-antiarrhythmic, may slightly affect the fibrillation process in non-defined mechanisms. We evaluated whether the most commonly used anaesthetic agent, propofol, affects AF patterns. Partial least-squares (PLS) analysis was performed to reduce significant noise into the main latent variables to find the differences between groups. The final results showed an excellent discrimination between groups with slow atrial activity during the propofol infusion.
Authors:
R Cervigón; J Moreno; R B Reilly; J Pérez-Villacastín; F Castells
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-26
Journal Detail:
Title:  Physiological measurement     Volume:  33     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1757-1768     Citation Subset:  -    
Affiliation:
Escuela Universitaria Politécnica, Campus Universitario, Group of Bioengineering Innovation (GIBI), DIEEAC, UCLM,. Camino del Pozuelo sn, E-16071, Cuenca, Spain.
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