Document Detail


Quantification of VEGF-C expression in canine mammary tumours.
MedLine Citation:
PMID:  18616481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tumours release angiogenic factors such as vascular endothelium growth factor (VEGF), which induces growth of a capillary network around the tumour. Elevated concentrations of VEGF have been reported in human mammary gland tumours. METHODS: To evaluate the expression of VEGF-C mRNA in canine mammary tissue, 38 mammary gland tumours (including 15 benign and 23 malignant mammary tumours), and 4 normal mammary glands were investigated by real-time reverse transcriptase quantitative polymerase chain reaction. RESULTS: VEGF-C expression in the malignant mammary tumours was much higher than in the benign mammary tumours or normal mammary tissue (P < 0.001). The expression of VEGF-C in tumours with lymph node metastasis was much higher than in those without (P < 0.01). CONCLUSION: The level of expression of VEGF-C did not correlate with tumour size or the patient's age, but was significantly higher in malignant mammary tumours and related to lymph node metastasis, making it a candidate marker for predicting metastasis of canine mammary cancer.
Authors:
C Qiu; D D Lin; H H Wang; C H Qiao; J Wang; T Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Australian veterinary journal     Volume:  86     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-11     Completed Date:  2008-10-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  279-82     Citation Subset:  IM    
Affiliation:
College of Veterinary Medicine, China Agricultural University, Beijing, PR China. csama@sina.com
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA, Complementary / analysis
Dog Diseases / metabolism*
Dogs
Female
Gene Expression Regulation, Neoplastic*
Immunohistochemistry / veterinary
Lymph Nodes / pathology
Lymphatic Metastasis
Mammary Neoplasms, Animal / blood supply,  metabolism*
RNA, Messenger / analysis,  metabolism
Receptors, Vascular Endothelial Growth Factor / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Markers, Biological
Vascular Endothelial Growth Factor C / analysis,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/RNA, Messenger; 0/Tumor Markers, Biological; 0/Vascular Endothelial Growth Factor C; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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