Document Detail


Quantification of surface amorphous content using dispersive surface energy: the concept of effective amorphous surface area.
MedLine Citation:
PMID:  21725707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigate the use of dispersive surface energy in quantifying surface amorphous content, and the concept of effective amorphous surface area is introduced. An equation is introduced employing the linear combination of surface area normalized square root dispersive surface energy terms. This equation is effective in generating calibration curves when crystalline and amorphous references are used. Inverse gas chromatography is used to generate dispersive surface energy values. Two systems are investigated, and in both cases surface energy data collected for physical mixture samples comprised of amorphous and crystalline references fits the predicted response with good accuracy. Surface amorphous content of processed lactose samples is quantified using the calibration curve, and interpreted within the context of effective amorphous surface area. Data for bulk amorphous content is also utilized to generate a thorough picture of how disorder is distributed throughout the particle. An approach to quantifying surface amorphous content using dispersive surface energy is presented. Quantification is achieved by equating results to an effective amorphous surface area based on reference crystalline, and amorphous materials.
Authors:
Jeffrey Brum; Daniel Burnett
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Publication Detail:
Type:  Journal Article     Date:  2011-07-02
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  12     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-31     Completed Date:  2012-03-25     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-92     Citation Subset:  IM    
Affiliation:
Physical Properties, Particle Generation, Engineering and Control, Product Development, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA. jeffrey.brum@gsk.com
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Chemistry, Physical
Chromatography, Gas
Drug Compounding
Lactose / chemistry*
Physicochemical Phenomena
Surface Properties
Technology, Pharmaceutical*
Chemical
Reg. No./Substance:
63-42-3/Lactose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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