| Quantification of Pre-systolic Blood Flow Organization and Energetics in the Human Left Ventricle. | |
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MedLine Citation:
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PMID: 21421820 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Intracardiac blood flow patterns are potentially important to cardiac pumping efficiency. However, these complex flow patterns remain incompletely characterized both in health and disease. We hypothesized that normal left ventricular (LV) blood flow patterns would preferentially optimize a portion of the end-diastolic volume (LVEDV) for effective and rapid systolic ejection, by virtue of location near and motion towards the LV outflow tract (LVOT). Three-dimensional cine velocity and morphological data were acquired in 12 healthy persons and one patient with dilated cardiomyopathy using MRI. A previously validated method was used for analysis in which the LVEDV was separated into four functional flow components based on the blood's locations at the beginning and end of the cardiac cycle. Each component's volume, kinetic energy (KE), site, direction and linear momentum relative to the LVOT were calculated. Of the 4 components, the LV inflow that passes directly to outflow in a single cardiac cycle (Direct Flow), had the largest volume. At the time of isovolumic contraction, Direct Flow had the greatest amount of KE, and the most favorable combination of distance, angle, and linear momentum relative to the LVOT. Atrial contraction boosted the late diastolic KE of the ejected components. We conclude that normal diastolic LV flow creates favorable conditions for ensuing ejection, defined by proximity and energetics, for the Direct Flow, and that atrial contraction augments the end-diastolic KE of the ejection volume. The correlation of Direct Flow characteristics with ejection efficiency might be a relevant investigative target in cardiac failure. |
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Authors:
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Jonatan Eriksson; Petter Dyverfeldt; Jan Engvall; Ann F Bolger; Tino Ebbers; Carl Johan Carlhäll |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-18 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: - ISSN: 1522-1539 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Linköping University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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