Document Detail

Quantification of Intracranial Aneurysm Morphodynamics from ECG-gated CT Angiography.
MedLine Citation:
PMID:  22884403     Owner:  NLM     Status:  Publisher    
RATIONALE AND OBJECTIVES: Aneurysm morphodynamics is potentially relevant for assessing aneurysm rupture risk. A method is proposed for automated quantification and visualization of intracranial aneurysm morphodynamics from electrocardiogram (ECG)-gated computed tomography angiography (CTA) data. MATERIALS AND METHODS: A prospective study was performed in 19 aneurysms from 14 patients with diagnostic workup for recently discovered aneurysms (n = 15) or follow-up of untreated known aneurysms (n = 4). The study was approved by the Institutional Review Board of the hospital and written informed consent was obtained from each patient. An image postprocessing method was developed for quantifying aneurysm volume changes and visualizing local displacement of the aneurysmal wall over a heart cycle using multiphase ECG-gated (four-dimensional) CTA. Percentage volume changes over the heart cycle were determined for aneurysms, surrounding arteries, and the skull. RESULTS: Pulsation of the aneurysm and its surrounding vasculature during the heart cycle could be assessed from ECG-gated CTA data. The percentage aneurysmal volume change ranged from 3% to 18%. CONCLUSION: ECG-gated CTA can be used to study morphodynamics of intracranial aneurysms. The proposed image analysis method is capable of quantifying the volume changes and visualizing local displacement of the vascular structures over the cardiac cycle.
Azadeh Firouzian; Rashindra Manniesing; Coert T Metz; Roelof Risselada; Stefan Klein; Fop van Kooten; Miriam C J M Sturkenboom; Aad van der Lugt; Wiro J Niessen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Academic radiology     Volume:  -     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 AUR. Published by Elsevier Inc. All rights reserved.
Department of Medical Informatics, Erasmus MC-University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Radiology, Erasmus MC-University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
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