Document Detail


Quantification of HCV RNA levels and detection of core antigen in donations before seroconversion.
MedLine Citation:
PMID:  12385415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Detection of HCV during the window phase of infection before seroconversion is important in blood screening. HCV RNA levels were measured before seroconversion and compared with HCV core antigen and anti-HCV detection. STUDY DESIGN AND METHODS: A total of 41 plasma samples from 17 US plasmapheresis donors and one English National Blood Service donor in the window phase before seroconversion of HCV infection were tested for the presence of anti-HCV, HCV RNA, and HCV core antigen. RESULTS: HCV RNA levels between 5.4 x 10(2) and 3.4 x 10(7) IU per mL were measured. HCV core antigen was detected in 11 of 18 donors at the same time point as RNA was detected. CONCLUSIONS: A wide range of HCV RNA levels can be detected during the seronegative window phase of HCV infection. HCV core antigen can be used to detect HCV infection during the window phase of infection.
Authors:
P R Grant; C M Sims; R S Tedder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transfusion     Volume:  42     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-18     Completed Date:  2002-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-6     Citation Subset:  IM    
Affiliation:
Department of Virology, Royal Free and University College Medical School, London, United Kingdom. paul.grant@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Antigen-Antibody Reactions*
Blood Donors*
Enzyme-Linked Immunosorbent Assay / methods
Hepacivirus / genetics*,  immunology*
Hepatitis C Antigens / analysis*
Humans
RNA, Viral / analysis*
Reverse Transcriptase Polymerase Chain Reaction
Viral Core Proteins / analysis*
Chemical
Reg. No./Substance:
0/Hepatitis C Antigens; 0/RNA, Viral; 0/Viral Core Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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