| Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA. | |
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MedLine Citation:
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PMID: 16230903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to develop and validate a pharmacokinetic model allowing description of the magnetic resonance (MR) signal intensity induced by the hepatobiliary contrast agent Gd-BOPTA and to quantify the overall Gd-BOPTA transport in rat liver. MATERIALS AND METHODS: MR signal intensity was recorded during the perfusion of rat livers with Gd-DTPA, an extracellular contrast agent, and Gd-BOPTA, a hepatobiliary contrast agent. Similar experiments were conducted with Gd-labeled contrast agents for quantitative measurement in liver, bile and perfusate. RESULTS: A complete 6-compartment, 8 parameter open model was first developed to describe the pharmacokinetics of the compound based on the radioactivity data analysis. Because perfusate and bile data were not available in MRI experiments, a reduced model (6-compartment, 5 parameters) was considered for the MRI data. The performance of the reduced model was tested using the radioactivity data. The reduced model successfully described the contrast agent amount in the liver and correctly predicted amounts in bile and perfusate. CONCLUSIONS: Pharmacokinetic modeling of MR signal intensity induced by Gd-BOPTA permits quantification of Gd-BOPTA uptake and biliary excretion in rat livers. |
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Authors:
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Corinne Planchamp; Catherine M Pastor; Luc Balant; Christoph D Becker; François Terrier; Marianne Gex-Fabry |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Investigative radiology Volume: 40 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-18 Completed Date: 2006-01-12 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 705-14 Citation Subset: IM |
Affiliation:
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Department of Radiology, Geneva University Hospitals, Geneva, Switzerland. corinne.planchamp@hcuge.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism* Biological Transport Contrast Media / pharmacokinetics* Extracellular Space / metabolism Gadolinium DTPA / pharmacokinetics* Liver / metabolism* Magnetic Resonance Imaging Meglumine / analogs & derivatives*, pharmacokinetics Models, Biological Organometallic Compounds / pharmacokinetics* Perfusion Rats Rats, Sprague-Dawley Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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