Document Detail

Quantification of dose nonuniformities by voxel-based dosimetry in patients receiving 90Y-ibritumomab-tiuxetan.
MedLine Citation:
PMID:  23289952     Owner:  NLM     Status:  MEDLINE    
METHODS: Eleven lesions from seven patients with either indolent or aggressive non-Hodgkin lymphoma were analyzed, along with four organs with disease. Absorbed doses were estimated by a direct integration of single-voxel kinetic data from serial tomographic images. After proper corrections, differential BED distributions and surviving cell fractions were estimated, allowing for the calculation of EU-BED. To quantify dose uniformity in each target area, a heterogeneity index was defined.
RESULTS: Average doses were below those prescribed by conventional radiotherapy to eradicate lymphoma lesions. Dose heterogeneity and effect on tumor control varied among lesions, with no apparent relation to tumor mass. Although radiation doses to involved organs were safe, unexpected liver toxicity occurred in one patient who presented with a pattern of diffuse infiltration.
CONCLUSION: Voxel-based dosimetry and radiobiologic modeling can be successfully applied to lesions and tumor-involved organs, representing a methodological advance over estimation of mean absorbed doses. However, effects on tumor control and organ toxicity still cannot be easily predicted.
Francesco Cicone; Marco D'Arienzo; Andrea Carpaneto; Eleonora Russo; Angela Coniglio; Angelika Bischof Delaloye; Francesco Scopinaro
Publication Detail:
Type:  Journal Article     Date:  2013-01-04
Journal Detail:
Title:  Cancer biotherapy & radiopharmaceuticals     Volume:  28     ISSN:  1557-8852     ISO Abbreviation:  Cancer Biother. Radiopharm.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-08-15     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9605408     Medline TA:  Cancer Biother Radiopharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-107     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / pharmacokinetics,  therapeutic use*
Lymphoma, Non-Hodgkin / pathology,  radionuclide imaging,  radiotherapy*
Middle Aged
Neoplasm Grading
Radiotherapy Dosage
Tissue Distribution
Treatment Outcome
Yttrium Radioisotopes / pharmacokinetics,  therapeutic use*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Yttrium Radioisotopes; 0/ibritumomab tiuxetan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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