Document Detail


Quantification of age-related and per diopter accommodative changes of the lens and ciliary muscle in the emmetropic human eye.
MedLine Citation:
PMID:  23287789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To calculate age-related and per diopter (D) accommodative changes in crystalline lens and ciliary muscle dimensions in vivo in a single cohort of emmetropic human adults ages 30 to 50 years.
METHODS: The right eyes of 26 emmetropic adults were examined using ultrasonography, phakometry, anterior segment optical coherence tomography, and high resolution magnetic resonance imaging. Accommodation was measured both subjectively and objectively.
RESULTS: In agreement with previous research, older age was linearly correlated with a thicker lens, steeper anterior lens curvature, shallower anterior chamber, and lower lens equivalent refractive index (all P < 0.01). Age was not related to ciliary muscle ring diameter (CMRD) or lens equatorial diameter (LED). With accommodation, lens thickness increased (+0.064 mm/D, P < 0.001), LED decreased (-0.075 mm/D, P < 0.001), CMRD decreased (-0.105 mm/D, P < 0.001), and the ciliary muscle thickened anteriorly (+0.013 to +0.026 mm/D, P < 0.001) and thinned posteriorly (-0.011 to -0.015, P < 0.01). The changes per diopter of accommodation in LED, CMRD, and ciliary muscle thickness were not related to subject age.
CONCLUSIONS: The per diopter ciliary muscle contraction is age independent, even as total accommodative amplitude declines. Quantifying normal biometric dimensions of the accommodative structures and changes with age and accommodative effort will further the development of new IOLs designed to harness ciliary muscle forces.
Authors:
Kathryn Richdale; Loraine T Sinnott; Mark A Bullimore; Peter A Wassenaar; Petra Schmalbrock; Chiu-Yen Kao; Samuel Patz; Donald O Mutti; Adrian Glasser; Karla Zadnik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-07
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  54     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-04-24     Revised Date:  2013-08-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-105     Citation Subset:  IM    
Affiliation:
College of Optometry, State University of New York, New York, NY, USA. KRichdale@SUNYopt.edu
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MeSH Terms
Descriptor/Qualifier:
Accommodation, Ocular / physiology*
Adult
Aging / physiology*
Biometry
Ciliary Body / anatomy & histology,  physiology*
Emmetropia / physiology*
Female
Humans
Lens, Crystalline / physiology*,  ultrasonography
Magnetic Resonance Imaging
Male
Middle Aged
Muscle, Smooth / anatomy & histology,  physiology*
Refraction, Ocular / physiology
Tomography, Optical Coherence
Visual Acuity / physiology
Grant Support
ID/Acronym/Agency:
K23-EY019097/EY/NEI NIH HHS; U10-EY08893/EY/NEI NIH HHS; UL1 TR000090/TR/NCATS NIH HHS
Comments/Corrections
Comment In:
Invest Ophthalmol Vis Sci. 2013 Mar;54(3):1857-8   [PMID:  23485633 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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