| Quantification of 3-methylglutaconic acid in urine, plasma, and amniotic fluid by isotope-dilution gas chromatography/mass spectrometry. | |
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MedLine Citation:
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PMID: 8111960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A method is described for quantification of the trace metabolite, 3-methylglutaconic acid, by isotope-dilution gas chromatography/mass spectrometry using synthetic 3-[2,4,6-13C3]methylglutaconic acid. Results are shown for quantification of 3-methylglutaconic acid in plasma, urine, cerebrospinal fluid and amniotic fluid for both normal controls and patients with different forms of 3-methylglutaconic aciduria. A simple method for the synthesis and purification of 3-[2,4,6-13C3]methylglutaconic acid is also described. |
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Authors:
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R I Kelley |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 220 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-03-28 Completed Date: 1994-03-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 157-64 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry Child Child, Preschool Gas Chromatography-Mass Spectrometry / methods* Glutarates / analysis*, blood, cerebrospinal fluid, urine Humans Infant |
| Grant Support | |
ID/Acronym/Agency:
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DK-44933/DK/NIDDK NIH HHS; HD-07107/HD/NICHD NIH HHS; HD-10981/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutarates; 5746-90-7/3-methylglutaconic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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