Document Detail

Quality of systematic reviews in pediatric oncology--a systematic review.
MedLine Citation:
PMID:  19836897     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To ensure evidence-based decision making in pediatric oncology systematic reviews are necessary. The objective of our study was to evaluate the methodological quality of all currently existing systematic reviews in pediatric oncology. METHODS: We identified eligible systematic reviews through a systematic search of the literature. Data on clinical and methodological characteristics of the included systematic reviews were extracted. The methodological quality of the included systematic reviews was assessed using the overview quality assessment questionnaire, a validated 10-item quality assessment tool. We compared the methodological quality of systematic reviews published in regular journals with that of Cochrane systematic reviews. RESULTS: We included 117 systematic reviews, 99 systematic reviews published in regular journals and 18 Cochrane systematic reviews. The average methodological quality of systematic reviews was low for all ten items, but the quality of Cochrane systematic reviews was significantly higher than systematic reviews published in regular journals. On a 1-7 scale, the median overall quality score for all systematic reviews was 2 (range 1-7), with a score of 1 (range 1-7) for systematic reviews in regular journals compared to 6 (range 3-7) in Cochrane systematic reviews (p<0.001). CONCLUSION: Most systematic reviews in the field of pediatric oncology seem to have serious methodological flaws leading to a high risk of bias. While Cochrane systematic reviews were of higher methodological quality than systematic reviews in regular journals, some of them also had methodological problems. Therefore, the methodology of each individual systematic review should be scrutinized before accepting its results.
Andreas Lundh; Sebastiaan L Knijnenburg; Anders W Jørgensen; Elvira C van Dalen; Leontien C M Kremer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer treatment reviews     Volume:  35     ISSN:  1532-1967     ISO Abbreviation:  Cancer Treat. Rev.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-26     Completed Date:  2009-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502030     Medline TA:  Cancer Treat Rev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  IM    
Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
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MeSH Terms
Bias (Epidemiology)
Evidence-Based Medicine
Journalism, Medical / standards*
Medical Oncology*
Meta-Analysis as Topic*
Research Design / standards*
Review Literature as Topic*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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