Document Detail

Quality of life and survival in patients with heart failure.
MedLine Citation:
PMID:  22989869     Owner:  NLM     Status:  MEDLINE    
AIMS: To examine whether self-rated disease-specific and generic quality of life predicts long-term mortality, independent of brain natriuretic peptide (BNP) levels, and to explore factors related to low quality of life in a well-defined heart failure (HF) population.
METHODS AND RESULTS: A cohort of 661 patients (62% male; age 71 years; left ventricular ejection fraction 34%) was followed prospectively for 3 years. Quality of life questionnaires (Ladder of Life, RAND36, and Minnesota Living with Heart Failure Questionnaire) and BNP levels were assessed at discharge after a hospital admission for HF. Three-year mortality was 42%. After adjustment for demographic variables, clinical variables, and BNP levels, poor quality of life scores predicted higher mortality; per 10 units on the physical functioning [hazard ratio (HR) 1.08, 95% confidence interval (CI) 1.02-1.14] and general health (HR 1.08, 95% CI 1.01-1.16) dimensions of the RAND36. Patients with low scores on these dimensions were more likely to be in New York Heart Association class III-IV, diagnosed with co-morbidities, have suffered longer from HF, have lower estimated glomerular filtration rates, and have fewer beta-blocker prescriptions.
CONCLUSION: Quality of life was independently related to survival in a cohort of hospitalized patients with HF.
Tialda Hoekstra; Tiny Jaarsma; Dirk J van Veldhuisen; Hans L Hillege; Robbert Sanderman; Ivonne Lesman-Leegte
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  European journal of heart failure     Volume:  15     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-05-21     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  94-102     Citation Subset:  IM    
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MeSH Terms
Follow-Up Studies
Heart Failure / mortality*,  physiopathology,  psychology*
Netherlands / epidemiology
Prospective Studies
Quality of Life*
Severity of Illness Index
Survival Rate / trends
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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