Document Detail


Quality of life, self-esteem, fatigue, and sexual function in young men after cancer: a controlled cross-sectional study.
MedLine Citation:
PMID:  20186765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Androgen deficiency is increasingly recognized in young male cancer survivors; however, its impact on quality of life (QOL) is not established. The authors investigated the relationship between androgen levels, QOL, self-esteem, fatigue, and sexual function in young male cancer survivors compared with control subjects. METHODS: A cross-sectional, observational study of 176 male cancer survivors and 213 male controls aged 25 to 45 years was performed. Subjects completed 3 QOL scales (Medical Outcomes Study 36-Item Short-Form Health Survey version 2, the 12-item General Health Questionnaire [GHQ-12], and Aging Male Scale), and measures of self-esteem (Rosenberg Self-Esteem Scale), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), and sexual function (Derogatis Interview for Sexual Functioning-II Self-Report-Male). RESULTS: Cancer survivors had lower scores for all components of the Short-Form Health Survey, Aging Male Scale, and Functional Assessment of Chronic Illness Therapy-Fatigue, and for 4 of 5 subsections of the Derogatis Interview for Sexual Functioning than controls. The majority of these differences remained after adjusting by linear regression analysis. Levels of psychiatric disorder or self-esteem did not differ between the 2 groups. In cancer survivors, those with androgen deficiency (serum testosterone < or = 10 nmol/L) had lower scores than those without for all components of the Short-Form Health Survey, the General Health Questionnaire, Functional Assessment of Chronic Illness Therapy-Fatigue, and the Derogatis Interview for Sexual Functioning. Serum testosterone only weakly correlated with health measures. CONCLUSIONS: Young male cancer survivors self-report a marked impairment in QOL, energy levels, and quality of sexual functioning, and this was exacerbated in those with androgen deficiency. However, psychological distress was not elevated, self-esteem was normal, and sexual relationships were not impaired. The relationship with testosterone is complex, and appears dependent on a threshold level rather than direct correlation. Interventional trials are needed to determine whether testosterone replacement would improve QOL in young male cancer survivors.
Authors:
Diana M Greenfield; Stephen J Walters; Robert E Coleman; Barry W Hancock; John A Snowden; Stephen M Shalet; Leonard R DeRogatis; Richard J M Ross
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  116     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-04-26     Revised Date:  2010-06-01    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1592-601     Citation Subset:  AIM; IM    
Affiliation:
Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Androgens / deficiency*
Cross-Sectional Studies
Fatigue / etiology*
Health Status
Humans
Male
Neoplasms / physiopathology*,  psychology*
Quality of Life*
Self Concept*
Sexual Dysfunction, Physiological / etiology*
Survivors*
Chemical
Reg. No./Substance:
0/Androgens
Comments/Corrections
Comment In:
Nat Rev Endocrinol. 2010 Jun;6(6):299

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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