| Quality of life, self-esteem, fatigue, and sexual function in young men after cancer: a controlled cross-sectional study. | |
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MedLine Citation:
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PMID: 20186765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Androgen deficiency is increasingly recognized in young male cancer survivors; however, its impact on quality of life (QOL) is not established. The authors investigated the relationship between androgen levels, QOL, self-esteem, fatigue, and sexual function in young male cancer survivors compared with control subjects. METHODS: A cross-sectional, observational study of 176 male cancer survivors and 213 male controls aged 25 to 45 years was performed. Subjects completed 3 QOL scales (Medical Outcomes Study 36-Item Short-Form Health Survey version 2, the 12-item General Health Questionnaire [GHQ-12], and Aging Male Scale), and measures of self-esteem (Rosenberg Self-Esteem Scale), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), and sexual function (Derogatis Interview for Sexual Functioning-II Self-Report-Male). RESULTS: Cancer survivors had lower scores for all components of the Short-Form Health Survey, Aging Male Scale, and Functional Assessment of Chronic Illness Therapy-Fatigue, and for 4 of 5 subsections of the Derogatis Interview for Sexual Functioning than controls. The majority of these differences remained after adjusting by linear regression analysis. Levels of psychiatric disorder or self-esteem did not differ between the 2 groups. In cancer survivors, those with androgen deficiency (serum testosterone < or = 10 nmol/L) had lower scores than those without for all components of the Short-Form Health Survey, the General Health Questionnaire, Functional Assessment of Chronic Illness Therapy-Fatigue, and the Derogatis Interview for Sexual Functioning. Serum testosterone only weakly correlated with health measures. CONCLUSIONS: Young male cancer survivors self-report a marked impairment in QOL, energy levels, and quality of sexual functioning, and this was exacerbated in those with androgen deficiency. However, psychological distress was not elevated, self-esteem was normal, and sexual relationships were not impaired. The relationship with testosterone is complex, and appears dependent on a threshold level rather than direct correlation. Interventional trials are needed to determine whether testosterone replacement would improve QOL in young male cancer survivors. |
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Authors:
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Diana M Greenfield; Stephen J Walters; Robert E Coleman; Barry W Hancock; John A Snowden; Stephen M Shalet; Leonard R DeRogatis; Richard J M Ross |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 116 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-04-26 Revised Date: 2010-06-01 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1592-601 Citation Subset: AIM; IM |
Affiliation:
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Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Androgens / deficiency* Cross-Sectional Studies Fatigue / etiology* Health Status Humans Male Neoplasms / physiopathology*, psychology* Quality of Life* Self Concept* Sexual Dysfunction, Physiological / etiology* Survivors* |
| Chemical | |
Reg. No./Substance:
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0/Androgens |
| Comments/Corrections | |
Comment In:
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Nat Rev Endocrinol. 2010 Jun;6(6):299 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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