Document Detail

Quality of life of schizophrenic patients on medications and implications for new drug trials.
MedLine Citation:
PMID:  1348238     Owner:  NLM     Status:  MEDLINE    
The quality of life of schizophrenic patients participating in clinical trials of new neuroleptics is rarely systematically assessed. Factors that may have contributed to the neglect of such assessments include the difficulty of measuring changes affecting quality of life during short-term trials and the continued belief that schizophrenic patients' self-reports about inner states are unreliable. A model of determinants specifically related to the quality of life of schizophrenic patients in such trials would include symptoms, side effects of neuroleptics, and psychosocial performance. In view of the importance of assessing the quality of life of patients on medications, the author recommends that regulatory agencies require such assessments in clinical trials of new neuroleptics.
A G Awad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hospital & community psychiatry     Volume:  43     ISSN:  0022-1597     ISO Abbreviation:  Hosp Community Psychiatry     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0040250     Medline TA:  Hosp Community Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-5     Citation Subset:  IM    
Wellesley Hospital, Toronto, Ontario, Canada.
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MeSH Terms
Activities of Daily Living / psychology
Antipsychotic Agents / adverse effects,  therapeutic use*
Psychiatric Status Rating Scales
Quality of Life*
Schizophrenia / drug therapy*
Schizophrenic Psychology*
Social Adjustment
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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