Document Detail

Quality of life restored to normal in patients with atrial fibrillation after pulmonary vein ostial isolation.
MedLine Citation:
PMID:  15309003     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary vein isolation (PVI) is effective in patients with paroxysmal atrial fibrillation. However, its impact on quality of life (QOL) is not completely understood. METHODS: Eighty-nine otherwise healthy patients (74 men; age, 53 +/- 11 years) were selected for PVI. The Medical Outcomes Short Form 36 (SF-36) and the Symptom Checklist (SCL) QOL questionnaires were obtained before PVI and for as long as 6 months after PVI. RESULTS: A total of 294 PVs (3.3 PVs/patient) were targeted in 125 procedures (1.4/patient). After a mean follow-up period of 191 +/- 109 days, scores for SCL frequency (19.09 +/- 8.07 vs 10.67 +/- 6.61), SCL severity (15.97 +/- 7.68 vs 9.72 +/- 5.98), SF-36 physical composite (45.43 +/- 9.70 vs 51.70 +/- 6.52), and SF-36 mental composite (44.50 +/- 11.33 vs 51.67 +/- 8.73) improved significantly (P <.0001 each). Seventy-five patients provided data at both the baseline and a late (3- or 6-month) follow-up. This cohort had significantly worse QOL scores in 7 of the 8 SF-36 subscales at baseline compared with age-matched healthy control subjects, but their QOL scores were similar to a comparison group of 152 previously reported patients with atrial fibrillation receiving drug treatment who had similar demographic and clinical variables. After PVI, patients improved significantly, resulting in equivalence with the healthy control population. Logistic regression analysis of demographic variables and baseline QOL scores revealed no significant predictors of PVI responders. CONCLUSIONS: QOL measures in patients with paroxysmal atrial fibrillation are severely depressed before PVI. Within a 6-month follow-up period after ablation, SF-36 subscale scores were restored to equivalence with an age-matched, healthy control population. Neither demographic or clinical variables nor baseline QOL scores were predictive of response to PVI.
Helmut Pürerfellner; Martin Martinek; Josef Aichinger; Hans Joachim Nesser; Kitty Kempen; Jacques P G Janssen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  148     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2005-01-13     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-25     Citation Subset:  AIM; IM    
Cardiological Department, Elisabethinen Academic Teaching Hospital, Linz, Austria.
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MeSH Terms
Atrial Fibrillation / surgery*
Catheter Ablation / methods*
Longitudinal Studies
Middle Aged
Pulmonary Veins
Quality of Life*
Regression Analysis

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