Document Detail

Quality of life and its relation to cancer-related stress in women of families with hereditary cancer without demonstrated mutation.
MedLine Citation:
PMID:  16547785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although quality of life (QoL) and mental distress in women belonging to familial cancer families have been studied, little is known on these matters in women with absence of demonstrated mutations. The aim of this study was to examine QoL and cancer-related distress in such women. METHODS: About 330 women at risk for familial cancers in the absence of demonstrated mutations were invited to the study. About 239 women (72%) (risk group) completed the Short Form 12 (SF-12) and the Impact of Event Scale (IES). The SF-12-findings were compared to the age-adjusted findings from the general female population (controls). RESULTS: The risk group had significantly better physical QoL than controls, while no significant difference was found for mental QoL. Within the risk group the type of familial cancer did not make a significant difference in QoL, but to have a father with cancer or a deceased parent, was associated with increased risk of being a case with low QoL. Mental QoL showed moderate correlation with cancer-related distress. CONCLUSIONS: Women belonging to familial cancer families in the absence of demonstrated mutations had at least as good QoL as controls in spite of living with a permanent cancer-related threat.
Amy Østertun Geirdal; Lovise Maehle; Ketil Heimdal; Astrid Stormorken; Pål Møller; Alv A Dahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation     Volume:  15     ISSN:  0962-9343     ISO Abbreviation:  Qual Life Res     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9210257     Medline TA:  Qual Life Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  461-70     Citation Subset:  IM    
Section for Genetic Counselling, Department of Cancer Genetics, Rikshospitalet-Radiumhospitalet Trust, 0310, Montebello, Oslo, Norway.
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MeSH Terms
Genetic Predisposition to Disease*
Middle Aged
Neoplasms / genetics*,  psychology*
Quality of Life*
Stress, Psychological*

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