Document Detail

Quality of life in patients with various liver diseases: Patients with HCV show greater mental impairment, while patients with PBC have greater physical impairment.
MedLine Citation:
PMID:  20337922     Owner:  NLM     Status:  In-Data-Review    
Summary.  Little is known comparing and contrasting quality of life (QoL) in patients with hepatitis C, compared to patients with other liver diseases. We performed two independent prospective cross-sectional studies including 511 and 284 patients with different forms of liver diseases. SF-36 was used in both studies. Fatigue Impact Score, WHO-BREF and Hospital Anxiety and Depression Scale (HADS) were used in either study only. In both studies, HCV-positive patients scored worse in the mental aspects of health-related QoL compared to other liver diseases, except for HBV in one study. Surprisingly, in both studies, quality of life was also significantly impaired in patients with viral clearance after interferon therapy but not after spontaneous clearance. Furthermore, patients with primary biliary cirrhosis showed significantly better mental health but significantly worse physical well-being. Liver diseases differ in their form of impaired QoL. In HCV, this impairment might not always return to normal after treatment-induced viral clearance. This may suggest that HCV either may not be involved in QoL impairment or may induce a process which persists after viral clearance in some patients.
H L Tillmann; M Wiese; Y Braun; J Wiegand; S Tenckhoff; J Mössner; M P Manns; K Weissenborn
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  18     ISSN:  1365-2893     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  252-61     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Medizinische Hochschule Hannover, Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Hannover, Germany Duke University, Duke Clinical Research Institute, Durham, NC, USA Klinikum St. Georg GmbH, Leipzig, Germany Internistische Gemeinschaftspraxis, Hepatologie, Leipzig, Germany II. Medical Department, University Leipzig, Leipzig, Germany Medizinische Hochschule Hannover, Abteilung für Neurologie, Hannover, Germany.
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