| Quality of life in patients after long-term biochemical cure of Cushing's disease. | |
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MedLine Citation:
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PMID: 15741267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the long-term impact of cured Cushing's disease on subjective well-being, we assessed quality of life by validated health-related questionnaires in 58 patients cured from Cushing's disease by transsphenoidal surgery (n = 58), some of whom received additional radiotherapy (n = 11) and/or bilateral adrenalectomy (n = 3). The mean duration of remission was 13.4 +/- 6.7 yr (range of 2-25 yr). Patient data were compared with a control group of 98 healthy subjects with the same age and sex distribution and with age-adjusted reference values available from the literature. General perceived well-being, measured by the Nottingham Health Profile and the Short Form, was reduced compared with controls for all subscales (P < 0.001). Patients with Cushing's disease had worse scores on subscales of fatigue Multidimensional Fatigue Index and anxiety and depression (Hospital Anxiety and Depression Scale). Compared with reference values from the literature, quality of life was also reduced in the patients according to all questionnaires and all items, except pain (Short Form), sleep (Nottingham Health Profile), and reduced activity (Multidimensional Fatigue Index). Despite conventional hormone replacement therapy, hypopituitarism was an important independent predictor of reduced quality of life. Patients without hypopituitarism (n = 28) showed reduced scores on physical items but normal scores on mental items compared with controls. In conclusion, despite long-term cure of Cushing's disease, patients experience a considerable decrease in quality of life, with physical and psychosocial impairments, especially in the presence of hypopituitarism. |
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Authors:
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M O van Aken; A M Pereira; N R Biermasz; S W van Thiel; H C Hoftijzer; J W A Smit; F Roelfsema; S W J Lamberts; J A Romijn |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2005-03-01 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 90 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3279-86 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Female Follow-Up Studies Humans Hydrocortisone / urine Hypopituitarism / epidemiology Male Middle Aged Pituitary ACTH Hypersecretion / physiopathology*, psychology*, therapy Quality of Life* Questionnaires Reference Values |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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